Haisco Pharmaceuticals Pte. Ltd.

Sichuan Haiso Pharmaceutical Co., Ltd.

Zongjun Shi

Yao Li

Bo Xu

Lei Chen

Chen Zhang

Pangke Yan

Fei Ye

Xin Liu

Pingming Tang

Xiaobo Zhang

Wenjing Wang

Jia Ni

Yajun Wang

Guobiao Zhang

Dengyu Zheng

Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.

Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof

Disclosed are a fused tricyclic &#x3b3;-amino acid derivative and a medical use thereof, in particular, the present invention relates to a fused cyclic &#x3b3;-amino acid derivative as shown in general formula (I), or a stereoisomer, solvate, metabolite, prodrug, pharmaceutically acceptable salt or eutectic thereof, a pharmaceutical composition containing same, and the use of a compound or the composition in the field of analgesia, wherein the definitions of each substituent in general formula (I) are the same as the definitions in the description. 

Fused tricyclic &#x393;-amino acid derivative, preparation method therefor, and medical use thereof

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Sichuan, China

Zongjun Shi