Koninklijke Philips Corporation N.v.

The General Hospital Corporation

Zoltán Perkó

Matthieu Frédéric Bal

Jan Unkelbach

Fractionation optimization receives inputs including a radiation dose distribution to be delivered by fractionated radiation therapy, maximum and minimum number of fractions, and Biologically Effective Dose (BED) constraints for one or more organs-at-risk. A two-dimensional (2D) graph is displayed of a parameter X equal to or proportional to (I) versus a parameter Y equal to or proportional to (II) where N is the number of fractions, D is a total radiation dose to be delivered by the fractionated radiation therapy, and dis the fractional dose in fraction t. A constraint BED lines are displayed on the 2D graph depicting each BED constraint. A marker is displayed at a location on the 2D graph defined by a current fractionation and a current total dose. A new value for the current fractionation and/or the current total dose is received, and the marker is updated accordingly. Alternatively a second marker is displayed showing the new fractionation scheme along with its comparative advantages and disadvantages with respect to the current fractionation.

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Cambridge, MA, United States of America

Zoltán Perkó