Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag

Zoltán Katona

Tibor Mezei

Ferenc Lorant Bartha

Kálmán Nagy

Péter Trinka

Gyula Simig

Márta Porcs-Makkay

Gyula Lukacs

Györgyi Vereczkeyné Donáth

Gyula Lukács

Zsuzsanna Szent-Királlyi

József Reiter

László Pongó

Norbert Nemeth

Enikö Molnar

Györgyi Vereczekeyné Donath

Lászlö Pongo

Zsuzsanna Évinger

Jozsef BARKÓCZY

Judit Cselenyak

Gyorgyi Vereczkeyn Donáth

Donáth Györgyi Vereczkeyné

According to the present invention, 2-chloroethoxy-acetic acid-N,N-dimethylamide of the Formula (I) is prepared by reacting 2-hydroxyethoxy-acetic acid-N,N-dimethylamide of the Formula (II) in a solvent optionally in the presence of a catalyst with thionyl chloride and removing the solvent by distillation. 

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The present invention is related to 1-[(4-chlorophenyl)-phenylmethyl]-4-(2,2,2-trichloroethoxycarbonyl)-piperazine of the Formula (IV) and optically isomers thereof, process for preparation thereof and the use of the compound of the Formula (IV) in the preparation of 1-(4-chlorophenyl)-phenylmethyl-piperazine and optical isomers and salts thereof. 1-(4-chlorophenyl)-phenylmethyl-piperazine and optical isomers thereof are important intermediates in the preparation of non-sedating antihistamine-type active pharmaceutical ingredients. 

Optically active carbamates, process for preparation thereof and use thereof as pharmaceutical intermediates

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Eger, Hungary

Zoltán Katona