Gpc Biotech Ag

Morphosys Ag

Zoltan Nagy

Robert Rauchenberger

Michael Tesar

Tilmann Brandstetter

Elisabeth Thomassen-Wolf

Christoph Brunner

The present invention relates to compositions and methods for suppressing an immune response, e.g., by inhibiting class II MHC-mediated activation of T cells. The subject compounds and methods may be used to treat or prevent disorders such as rheumatoid arthritis and/or multiple sclerosis.

Immunosuppressant compounds, methods and uses related thereto

The present invention relates to polypeptide compositions which bind to cell surface epitopes and, in multivalent forms, cause or lead to the killing of cells including lymphoid tumor cells, and in the case of monovalent forms, cause immunosuppression or otherwise inhibit activation of lymphocytes. The invention further relates to nucleic acids encoding the polypeptides, methods for the production of the polypeptides, methods for killing cells, methods for immunosuppressing a patient, pharmaceutical, diagnostic and multivalent compositions and kits comprising the polypeptides and uses of the polypeptides.

Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells

Growing community of inventors

Wolfratshausen, Germany

Zoltan Nagy