Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Chinoin Gyogyszer Es Vegyeszeti

Chinoin Pharmaceutical and Chemical Works Ltd.

Zoltan Meszaros

Istvan Hermecz

Agnes Horvath

Jozsef Knoll

Sandor Virag

Agoston David

Lelle V Vasvari Nee Debreczy

Peter Szentmiklosi

Tibor Breining

Gabor Nagy

Gyula Sebestyen

Attila Mandi

Jozsef Kokosi

Gyorgy Szasz

Lelle Vasvari

Sandor Makleit

Rezso Bognar

Zsuzsanna Furst

Gyula Valovics

Gabor Bernath

Ferenc Fulop

Istvan Bitter

Tamas Szuts

Sandor J Nagy

Lelle Vasvari, Nee Debreczy

Tamas Szucs

Gabor Kovacs

Laszlo Tardos

Gabor Horvath

Jeno Marton

Klara Gyires

Peter Dvortsak

Josef Knoll

Lelle Vasvari Nee Debreczi

Istvan Bitteer

Lelle Vasuarl Nee Debreczy

Istvan Hermes

Jozse Knoll

Istvan Hurmecz

Laszo Tardos

Lelle Vasvari (nee Debreczy)

Laszlo Szlavik

Katalin Marmarosi (nee Kellner)

Ilona Erdelyi

Laszlo Szavik

Peter Szentmiklosy

Piroska Simon

A new method of treatment is disclosed for a vascular obstructive lesion resulting from restricted blood circulation, characterized by an erythrocyte pathology, in an effected animal subject. The new method involves the administration of 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydroisoquinolinium-theophylli ne-7-acetat e, in a dosage and at a rate sufficient to maintain a blood concentration of at least 0.5 to at most 3 .gamma./ml, calculated on the basis of 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydroisoquinoline.

Method of treating a vascular obstructive lesion resulting from

The invention relates to a process for the restoration and prevention of gastrointestinal injuries, which comprises treating a patient with an effective dose of racemic or optically active 1,6-dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrimido[1,2-a]pyrimidine-3-c arboxamide.

Treating process

New compounds of the following formula are disclosed:

Condensed pyrimidines

New 3-substituted-2-oxo-tetrahydro-pyrrolo[1,2-a]pyrimidines of the formula (II) ##STR1## or a pharmaceutically acceptable acid addition or quaternary ammonium salts thereof are disclosed, wherein

3-Substituted-2-oxo-tetrahydro-pyrrol[1,2-a]pyrimidines having

Antiphlogistic and anticoagulant compounds of the formula: ##STR1## wherein m is 0, 1 or 2,

New Rutecarpine analogs are disclosed having Rutecarpine-like activity, especially diuretic activity. Also a novel process for the preparation of the Rutecarpine analogs is disclosed.

Indolo[2',3';3,4]pyrido[2,1-b]quinazoline-5-ones, a process for the

Compounds of the formula I ##STR1## or pharmaceutically acceptable salts, hydrates, stereoisomers, optically active isomers, geometrical isomers or tautomeric forms thereof are disclosed wherein

Nitrogen bridgehead compounds having anti-allergic effect

New optionally racemic or optically active pyrimido(1,2a) heterocyclic compounds of the formula ##STR1## wherein m is 0, 1 or 2,

Antiphlogistic and anticoagulant condensed pyrimidine derivatives

3 Substituted hexahydro-pyrimido[1, 2 a]azepines and quaternary derivatives, useful as antianginals are prepared. Specifically tested are 3 carboxylates and carbo hydrazides. 3 Cyano Carbamonyl and alkyl compounds are also disclosed.

2-Oxo-2,6,7,8,9,10 hexahydro-pyrimido[1,2-a]azepines and antianginal

Intermediates useful in the preparation of Rutecarpine and Rutecarpine derivatives are disclosed as well as a process for the preparation of said intermediates having the following formula: ##STR1## wherein R, R.sup.1 and R.sup.2 are the same or different and stand for hydrogen, halogen, nitro, carboxy, nitrile, alkoxy containing 1 to 4 carbon atoms, alkoxycarbonyl containing 1 to 4 carbon atoms in the alkoxy group, alkyl containing 1 to 4 carbon atoms, amino or hydroxy or R and R.sup.1 together stand for methylenedioxy, R.sup.2 stands for hydrogen, R.sup.3 represents hydrogen or alkyl containing 1 to 4 carbon atoms, R.sup.4 stands for phenyl, phenyl substituted by 1 to 3 same or different substituents selected from the group of halogen(s), alkyl, and alkoxy containing 1 to 4 carbon atoms, phenyloxy, hydroxy, nitro, amino, cyano, carboxy, alkoxycarbonyl having 1 to 4 carbon atoms, alkanoyl having 1 to 4 carbon atoms, methylenedioxy, trifluoromethyl, phenyl and dialkylamino having 1 to 4 carbon atoms in the alkyl part or naphthyl and the dotted line indicated an optional double bond. Also pharmaceutically acceptable acid addition and quaternary ammonium salts are disclosed.

6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones

Chemical compounds having an effect on the circulatory system have the formulas ##STR1## or a mixture thereof, or a pharmaceutically suitable acid-addition salt or quaternary salt thereof, wherein

3-Substituted-tetrahydro-pyrrolo[1,2-a]pyrimidines and pharmaceutical

Nitrogen bridgehead compounds (pyrido-[1,2-a]-pyrimidine derivatives) which are useful intermediates in the making of known compounds of this class and which themselves possess PG-antagonist, analgesic, antiartheriosclerotic, tranquilizing and like pharmaceutical activity.

Substituted-4-oxo-1,6,7,8-tetrahydro-4H-pyrido[1,2-a]pyrimidines

Compounds of the formula ##STR1## or pharmaceutically acceptable acid-addition or quaternart ammonium salts thereof

Pyrido[1,2-A]pyrimidine derivatives and method of analgesic treatment

Antiallergic and antiasthmatic compounds of the formula ##STR1## of which 9-phenylamino-6-methyl-4-oxo-6,7-dihydro-4H-pyrido(1,2-a)pyrimidine-3-carb oxylic acid and optically active antipodes and salts thereof are examples.

Antiallergic nitrogen bridge-head compounds

An optically active or racemic fused pyrimidine derivative of the formula I ##STR1## has pharmaceutical activity in decreasing serum lipids, cholesterol deposits and, in general, against atherosclerosis.

Fused pyrimidine derivatives and antiatherosclerotic methods of

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Budapest, Hungary

Zoltan Meszaros