Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Zoltan Ecsery

Jozsef Knoll

Eva Somfai

Judit Hermann Nee Voros

Gabor Bernath

Zoltan Torok

Lajos T Nagy

Gabor T Szabo

Jeno Marton

Karoly Mozsolits

Eva Szinnyei

Matyas Szentivanyi

Katalin Kalloy

Otto Orban

Laslzo Arvai

Lajos Gera

Walter Birkmayer

Erzsebet Janvari, Nee Kanyo

Gyorgy Gondos

The invention relates to N-[2-(4-fluorophenyl)-1-methyl]-ethyl-N-methyl-N-propynyl amine of the Formula I ##STR1## and isomers and salts thereof. The compound of the Formula I is useful as an insecticide.

Pesticidal method

The invention relates to a synergistic pharmaceutical composition, which comprises as an active ingredient a combination of 1-phenylalanine and (-)-deprenyl [(-)-N-(1-phenylisopropyl)-N-methyl-N-propinylamine hydrochloride] and optionally carbidopa [3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methyl-propionic acid monohydrate] or benzerazide [N-(DL-seryl)-N'-( 2,3,4-trihydroxybenzyl)-hydrazine] in association with conventional inert, non-toxic solid or liquid pharamaceutical carriers. The invention further relates to the preparation of these compositions and to the use thereof for the treatment of depressive symptoms.

Synergistic pharmaceutical compositions, their production and use

The invention relates to a new process for the preparation of propargyl ammonium chlorides of the Formula I ##STR1## by alkaline decomposition of the d-tartarate of the 1-isomer of an amine of the Formula II ##STR2## and subsequent reaction of the amine of the Formula II with a halide of the Formula III

Process for the preparation of propargyl amines

A compound of the formula ##STR1## or a pharmaceutically effective salt thereof in which R.sup.1 and R.sup.2 are hydrogen or lower alkyl and R.sup.3 is halogenoalkenyl or propinyl. The compounds have pharmacological effects similar to those of phenylethylamine but are free from the amphetamine effect with an excellent therapeutic index and selectivity especially with respect to inhibition of monoaminooxidase.

N,N-Disubstituted-2-furylethyl amines

An antiedema compound of the formula: ##STR1## in which R.sup.1 is methyl, ethyl, cyclohexyl, phenyl, m-tolyl, p-tolyl, p-tert-butylphenyl, m-trifluoromethylphenyl, m-fluorophenyl, p-fluorophenyl, m-chlorophenyl, p-chlorophenyl, m-bromophenyl, p-bromophenyl, o-hydroxyphenyl, p-methoxyphenyl, p-nitrophenyl, benzyl, p-chlorobenzyl, m,p-dimethoxybenzyl, and o-pyridyl;

5,6-Dihydropyrimidin-4(3H)one derivatives, and antiedema compositions

Growing community of inventors

Budapest, Hungary

Zoltan Ecsery