Warner-lambert Company

Taro Pharmaceuticals U.s.a., Inc.

Zoltan Bodor

Zdravko Dokuzovic

Satish Asotra

Xiaoli Wang

Ramola Lewis

Costantina Kostantelou

Michael Glass

Leslie F Knebl

Joseph Hoholick

Eva K Malinowski

The invention relates to novel spill resistant formulations comprising either a weak base or a weak acid as the pharmaceutical ingredient, a liquid base, a clay and a water soluble cellulose ether. The clay and cellulose ether allow for a broader pH range into which the pharmaceutically active agent may be dispersed or dissolved, and therefore allows for easier preparation and formulation of the pharmaceutical composition.

Spill resistant formulations containing clays

The present inventive composition concerns a composite delivery system having a substantially hydrophobic exterior comprising:

Encapsulation matrix

Substantially anhydrous, non-staling chewing gum composition containing a homogenous premixture of a chewing gum base and a polyisobutylene having an average molecular weight of about 20,000 to about 100,000 in combination with a sweetening agent.

Anhydrous, non-staling chewing gum composition

A stabilized chewing gum product containing an L-aspartic acid derived sweetener in its free form and method for manufacture thereof are disclosed. The chewing gum product includes at least two portions, one of which includes, in its free form, Aspartame (APM) as an artificial, low calorie sweetener. Also included in the APM-containing portion can be an organic acid which will maintain the pH of the portion at a level conducive to maintaining the stability of APM. A second portion can include flavoring agents, and optionally, at least one moisture-containing agent. The portions are arranged in surface-to-surface relationship whereby contact between the APM and the flavorings and/or moisture-containing agent of the second portion is substantially reduced. The stability of APM and, consequently, of the chewing gum product is substantially increased.

Method and product for increased aspartame stability in chewing gum

A stabilized chewing gum product containing an L-aspartic acid derived sweetener and method for manufacture thereof are disclosed. The chewing gum product includes at least two portions, one of which includes Aspartame (APM) as an artificial, low calorie sweetener. A second portion can include a gum base and flavoring agents, preferably aldehyde flavorings. The portions are provided to opposite sides of a protective barrier film that is disposed between the two portions, whereby contact between the APM and the flavorings of the second portion is substantially reduced. The stability of APM and, consequently, of the chewing gum product is substantially increased.

Stabilized chewing gum product and method of making same

A hydrophilic plasticizing system which comprises a solution wherein gelatin is dissolved in a solution of sorbitol, glycerin and water and a chewing gum composition, which comprises: a chewing gum base, sweetening agent and the hydrophilic plasticizing system.

Novel hydrophilic plasticizing system and chewing gum containing same

A hydrophilic stabilizing system which comprises a solution wherein gelatin is dissolved in glycerin and water and a chewing gum composition, which comprises: a chewing gum base, sweetening agent and the hydrophilic stabilizing system.

Growing community of inventors

Pickering, Canada

Zoltan Bodor