US Government As Represented by the Secretary of the Army

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Zoltan Beck

Carl R Alving

Sheetij Dutta

Gary R Matyas

The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23&#xb0; C., and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a solublerecombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or arCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1.

recombinanr xiexumapoeozoite protein compositions and method for vaccine delivery

Provided herein is an adjuvant formulation comprising a monophosphoryl lipid A (MPLA)-containing liposome composition to saponin (e.g., QS-21), wherein the liposome composition comprises i) a lipid bilayer comprising phospholipids in which the hydrocarbon chains have a melting temperature in water of &#x2265;23&#xb0; C. and ii) cholesterol at a mole percent concentration of greater than about 50% (mol/mol), preferably about 55% to about 71% (mol/mol), or more preferably about 55% (mol/mol). The adjuvant formulation displays minimal toxicity of either lipid A or saponin.

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Rockville, MD, United States of America

Zoltan Beck