Sour Pliva

Pliva Farmaceutska Kemijska, Prehrambena I Kozmeticka Industrija S.p.o.

Zlatko Vajtner

Slobodan Djokic

Nevenka Lopotar

Bozidar Suskovic

Radmila Naumski

Hrvoje Krnjevic

Lidija Kolacny-Babic

The invention relates to the use of complexes and chelates resp., of antitics with bivalent and/or trivalent metals in antiulcer drugs, to new complexes and chelates resp., of antibiotics with bivalent and/or trivalent metals and to processes for the obtaining thereof.

Complexes and chelates of azithromycin with bivalent and/or trivalent

A complex of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-alanyl-D-isoglotaminyl- (L)-meso-diamino-pimelyl-(D-amide)-D-alanyl-D-alanine with bivalent metals chosen from the group comprising Cu.sup.2+, Zn.sup.2+, Co.sub.hu 2+ ; Ni.sup.2+ and Cd.sup.2+ in the molar ratio of the organic ligand: Cu.sup.2+ =2:1 and the organic ligand: Zn.sup.2+ or Co.sup.2+ or Ni.sup.2+ or Cd.sup.2+ =1:1, compositions containing it and their use in the treatment of immunological insufficiencies and disturbances in humans and animals.

Metal complexes of

New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen form the group comprising Cu.sup.+2, Zn.sup.+2, Co.sup.+2, Ni.sup.+2 and Ca.sup.+2, a process for their manufacture and their use in the manufacture of antibiotically active pharmaceuticals. New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen from the group comprising Cu.sup.+2, Zn.sup.+2, Co.sup.+2, Ni.sup.+2 and Ca.sup.+2 are made by reacting N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A in its free base form or in its water-soluble salt form with salts of said bivalent metals. The compounds possess antibiotic activity.

Metal complexes of N-methyl-11-aza-10-deoxo-10-dihydro-erythromycin A or

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Zagreb, Yugoslavia

Zlatko Vajtner