University of Kentucky Research Foundation

Ziyuan Zhou

Chang-Guo Zhan

Fang Zheng

Kai Ding

Shuo Zhou

Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.

Prostaglandin E synthase inhibitors and methods for utilizing the same

A method of treating pain is disclosed, which involves administering an effective amount of lapatinib or a pharmaceutically-acceptable salt thereof to a subject in need of treatment for pain.

Growing community of inventors

Lexington, KY, United States of America

Ziyuan Zhou