Mgi Tech Co., Ltd.

Ziyi Wu

Joyce Huang

Jay Shafto

Paul Lundquist

Yi Huang

Bin Yang

Xin Wen

Qian Deng

Heming Jiang

Craig Edward Uhrich

Chintang Yen

Yanqiao Huang

Mingyou Cao

Brian Keith Hauser

Embodiments of the disclosure include methods and systems for nucleic acid sequencing that may include an objective coupled to an actuator, wherein the actuator is configured to move the objective over a surface of a substrate. In some embodiments, a droplet may be disposed on the surface of the substrate, and the droplet may be moved along with the objective. The distal end of the objective may include a material that provides a higher friction against the droplet than a material of the surface of the substrate. In some embodiments, the distal end of the objective may be immersed in a fluid as it is moved over the surface of the substrate. The substrate may include vertical walls within a region to retain the fluid.

Systems and methods for optical scanning and imaging through a fluid medium for nucleic acid sequencing

An optical imaging system () is configured for photographing a sample and includes a lighting module () and an imaging module (). The lighting module () is configured for outputting excitation light, the excitation light is configured to excite the sample to generate excited light, the imaging module () comprises a time delay integration line scan camera (), the time delay integration line scan camera () is configured to record the excited light. A biochemical substance detection system using the optical imaging system () is also provided, improving the detection flux.

Optical imaging system and biochemical substance detection system using same

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Sunnyvale, CA, United States of America

Ziyi Wu