Impulse Dynamics Nv

Metacure N.v.

Onepass Medical Ltd.

Newpace Ltd.

Ziv Belsky

Yuval Mika

David Prutchi

Andre G Routh

Nissim Darvish

Edward Haluska

Shlomo Ben-Haim

Melina Flesler

Yaakov Ben Arie

Jesse Lachter

Gilad Hizkiyahu

Gera M Strommer

Yoav Kimchy

Dan Seter

Itzhak Shemer

Avraham Broder

Itzhak Shmarak

Jonathan Bar Or

Shay Policker

Mordechay Mocha

Apparatus, comprising: a sheath (), advanceable through an endoscope (), and having distal openings comprising a first opening () and a plurality of second openings () surrounding the first opening; a housing (), coupled to a proximal portion of the sheath; a first needle (), extending through the housing and sheath toward the first opening; a plurality of second needles (), extending through the housing and sheath toward a respective second opening; a first handle (), slidably coupled to the housing along an axis such that the first needle slides through the sheath and a distal tip of the first needle moves with respect to the first opening; and a second handle (), slidably coupled to the housing along a different axis such that the second needles slide through the sheath and a distal tip of each second needle moves with respect to its respective second opening.

Needle-handling device

Flexible semi-hermetic implantable medical device (IMD) structure, including a flexible device body, at least one flexible lead and at least one respective transition unit, for respectively coupling each flexible lead to the flexible device body, the flexible device body including a plurality of hermetically sealed components, at least one electrical cable harness and an external flexible polymer structure, each one of the hermetically sealed components including at least one hermetically sealed electrical connection and at least some of the hermetically sealed components including at least one separation dome, the electrical cable harness for electrically and mechanically coupling the plurality of hermetically sealed components together and the external flexible polymer structure for encapsulating the hermetically sealed components, the electrical cable harness and the respective transition unit.

Flexible semi-hermetic implantable medical device (IMD) structure

A cardiac contractility modulating (CCM) device () includes an anti-arrhythmic therapy unit () for detecting a cardiac arrhythmia in a heart () of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating (CCM) unit () capable of delivering cardiac contractility modulating (CCM) signals to the heart for modulating the contractility of a portion of the heart. The device () includes a power source (). The device may be an implantable device or a non-implantable device. A method for delivering anti-arrhythmic therapy to a heart. The method includes applying one or more non-excitatory cardiac contractility modulating electrical signals to said heart.

Anti-arrhythmic device and a method of delivering anti-arrhythmic cardiac therapy

A cardiac contractility modulating (CCM) device () includes an anti-arrhythmic therapy unit () for detecting a cardiac arrhythmia in a heart () of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating (CCM) unit () capable of delivering cardiac contractility modulating (CCM) signals to the heart for modulating the contractility of a portion of the heart. The device may provide to the anti-arrhythmic therapy unit control signals associated with the delivery of the CCM signals to the heart. The control signals may be used to prevent interference of the CCM signals with the detecting of the cardiac arrhythmia. The device () includes a power source. The device may be an implantable device or a non-implantable device. The device may also include a pacing unit.

Cardiac contractility modulation device having anti-arrhythmic capabilities and method of operating thereof

Apparatus is provided for treating a condition such as obesity. The apparatus includes a set of one or more electrodes, which are adapted to be applied to one or more respective sites in a vicinity of a body of a stomach of a patient. A control unit is adapted to drive the electrode set to apply to the body of the stomach a signal, configured such that application thereof increases a level of contraction of muscle tissue of the body of the stomach, and decreases a cross sectional area of a portion of the body of the stomach for a substantially continuous period greater than about 3 seconds.

Acute and chronic electrical signal therapy for obesity

A multi-modal cardiotherapy device () includes an anti-arrhythmic unit () for delivering multiple types of anti-arrhythmic therapy to a heart, a cardiac contractility modulating unit () for delivering cardiac contractility modulating signals to the heart, and for applying anti-arrhythmic cardiac contractility modulating signal therapy to the heart, one or more sensing units () for sensing electrical signals related to electrical activity of the heart to provide an output signal, one or more detecting units () operatively connected to the sensing unit(s) () for detecting in the output signal cardiac events of the heart, a controller unit () operatively connected to the anti-arrhythmic unit (), the cardiac contractility modulating unit () and the detecting unit(s) (). The controller unit () processes the output of the detecting unit(s) () to detect a cardiac arrhythmia or indications of a possible arrhythmia in the heart and controls the application of anti-arrhythmic therapy, anti-arrhythmic cardiac contractility modulating signal therapy, and cardiac contractility modulating therapy to the heart. The device may be an implantable device or a non-implantable device. The device () may also include a pacing unit (). Methods are disclosed for using the device for delivering multi-modal cardiotherapy to the heart.

Device for cardiac therapy

Apparatus is provided for treating a condition such as obesity. The apparatus includes a set of one or more electrodes, which are adapted to be applied to one or more respective sites in a vicinity of a body of a stomach of a patient. A control unit is adapted to drive the electrode set to apply to the body of the stomach a signal, configured such that application thereof increases a level of contraction of muscle tissue of the body of the stomach, and decreases a cross-sectional area of a portion of the body of the stomach for a substantially continuous period greater than about 3 seconds.

A cardiac contractility modulating (CCM) device includes an anti-arrhythmic therapy unit for detecting a cardiac arrhythmia in a heart of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating unit capable of delivering cardiac contractility modulating signals to the heart for modulating the contractility of a portion of the heart. The device may provide to the anti-arrhythmic therapy unit control signals associated with the delivery of the CCM signals to the heart. The control signals may be used to prevent interference of the CCM signals with the detecting of the cardiac arrhythmia. The device includes a power source. The device may be an implantable device or a non-implantable device. The device may also include a pacing unit.

Cardiac contractility modulation device having anti-arrhythmic capabilities and a method of operating thereof

A method for setting the parameters of an alert time window in an excitable tissue control device operative under a plurality of different cardiac conditions of a heart of a patient. The method includes providing said excitable tissue control device with a set of data including a plurality of sets of alert time window parameters. Each set of window parameters is uniquely associated with a different set of values of a plurality of cardiac condition defining parameters identifying one of the different cardiac conditions. Each set of window parameters includes at least a set of timing parameters usable for obtaining a beginning time point and an ending time point of the alert window. The sets of window parameters are obtained by processing data collected within a data collection session from a plurality of cardiac beats of the same patient under the different cardiac conditions.

Apparatus and method for setting the parameters of an alert window used for timing the delivery of ETC signals to a heart under varying cardiac conditions

A method and apparatus for modifying contractility of heart tissue. The method includes applying electrodes ( ) to one or more sites in the heart ( ) and making a determination at which of the sites, if any, to pace the heart. A parameter of an excitable tissue control (ETC) signal ( ) to be applied to the heart is set responsive to the determination, and the ETC signal is applied to at least one of the electrodes responsive to the parameter, so as to enhance contractility of the heart.

Trigger-based regulation of excitable tissue control of the heart

Apparatus and method for obtaining from a patient's heart data useful for on-line setting of the parameters of a detection time window in an excitable tissue control device. The method includes applying electrodes to a first cardiac site and a second cardiac site of a patient and electrically connecting the electrodes to a data collecting device. The device is then operated under a plurality of different cardiac conditions to obtain a plurality of different histogram data sets. Each histogram data set represents a cumulative time distribution histogram of cardiac depolarization events detected at the second cardiac site in a plurality of cardiac beats. Each histogram data set is defined by a plurality of histogram parameters having values indicative of the cardiac conditions common to the plurality of cardiac beats used to obtain the histogram data set. The histogram parameters include a sensitivity level parameter representing the sensitivity level used for detecting the cardiac depolarization events of the plurality of cardiac beats at the second cardiac site. Another histogram parameter represents the range of values of the beat to beat time interval for the beats who's data is included in the histogram data set. Another histogram parameter has values indicating if the beats who's data is included in the histogram data set were acquired under conditions in which the delivery of non-excitatory ETC signals substantially affected or did not substantially affect the velocity of propagation of depolarization waves in the myocardium. Another histogram parameter, which may be used in devices having pacing capability has values indicating whether the beats who's data is included in the histogram data set are paced beats or non-paced beats. The histogram data sets are processed for computing a set of data usable for on-line setting of the parameters of a detection time window. This set of data may then be used for operating an implanted or external ETC device operatively connected to the electrodes.

Apparatus and method for collecting data useful for determining the parameters of an alert window for timing delivery or ETC signals to a heart under varying cardiac conditions

A method and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of a portion of the heart are disclosed. The method includes the steps of applying electrodes to a plurality of cardiac sites, sensing electrical activity in a first cardiac site through a first electrode for detecting a first electrical depolarization event within a beat cycle, sensing electrical activity in a second cardiac site through a second electrode for detecting a second electrical depolarization event within the beat cycle, and applying a non-excitatory signal to the heart at or near at least the second cardiac site through at least one of the electrodes in response to detecting the second electrical depolarization event within an alert window period. The alert window period starts at a first delay from the time of detection of the first electrical depolarization event and has a first duration. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The method may include steps for reducing the probability of delivering of improperly timed non-excitatory signals due to electrical noise and/or ectopic beats and may also include steps for preventing delivery of multiple non-excitatory signals at or near the second cardiac site within a single cardiac beat cycle. Preferably, the first cardiac site is located about the right ventricle or the right atrium of the heart and the second cardiac site is located about the left ventricle of the heart. The devices may also be adapted for pacing the heart and/or for delivering defibrilation signals to the heart.

Apparatus and method for timing the delivery of non-excitatory ETC signals to a heart

A method and device for controlling the delivery of cardiac contractility modulating signals to the heart are disclosed. The method includes applying electrodes to a heart, sensing electrical activity in a first cardiac chamber and in at least a second cardiac chamber to detect events within a cardiac beat cycle and applying a cardiac contractility modulating signal to the heart at or about the first cardiac chamber in response to detecting an event within an alert window time interval. The applying of the cardiac contractility modulating signal is inhibited in response to detecting one or more inhibitory events occurring within specific time intervals defined within a current beat cycle. The method also includes the ignoring of events associated with expected electrical artifact signals if they occur within the duration of specified time intervals, to increase the therapy efficacy. The artifact signals may be associated with pacing of a cardiac chamber or with detected far field sensed electrical artifacts due to intrinsic chamber activation. The timing of the various time intervals and of the cardiac contractility signal may be computed on a beat by beat basis by utilizing a plurality of parameter sets stored in the device and the timing of events detected in each beat cycle. A method for determining and setting the parameter sets in a test session is disclosed.

Growing community of inventors

Haifa, Israel

Ziv Belsky