Shang Hai Innovative Research Center of Traditional Chinese Medicine

Zirong Yang

Changjiang Xu

Qiang Ge

Wenjing Zhang

Shoufu Lu

Jihua Wang

Chunying Yu

Yongzheng Hui

Qiyuan Han

Zhiqi Yang

Weiguo Jia

Qinlin Wang

An anti-fatigue composition consisting of 20(S)-protopanoxadiol andpolysaccharide. Experiments prove that the composition exhibits a significant anti-fatigue effect. In comparison with the effect attained by the single use ofpolysaccharide or 20(S)-protopanoxadiol, the combined use of 20(S)-protopanoxadiol andpolysaccharide exerts an obvious synergistic effect.

Anti-fatigue composition, formulation and use thereof

The present invention provides a protopanoxadiol derivative of structural formula I or II, a preparation method and an application thereof. The present invention performs structural modification on protopanoxadiol, and obtains multiple novel compounds with unique structures. As confirmed in vivo pharmacological experiments, these compounds have stronger anti-depression activity, can be used as an active ingredient in preparing medicine for preventing or treating depression-type mental illness, and have wide use and development prospect, 

Protopanoxadiol derivative, preparation method thereof and application thereof

The invention provides the novel use of 20(S)-protopanaxadiol in the preparation of medicaments for the treatment of depressive psychiatric disorders. The pharmacological test results indicated that the compound could remarkably increase the level of NE, 5-HT and HAV in the brains of model rats having depressive disorders, remarkably enhance tremors induced by 5-hydroxytryptophan (5-HTP) and behavioral effects induced by levodopa, and inhibit the re-uptake of 5-HT and NA.

Use of 20(S)-protopanaxadiol in manufacture of antidepressants

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Shanghai, China

Zirong Yang