Purdue Research Foundation

Ziqing Lin

Zheng Ouyang

Robert Graham Cooks

Chien-hsun Chen

Livia Schiavinato Eberlin

Yue Ren

Livia Schiavinato

The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

Systems and methods for quantifying an analyte extracted from a sample

The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

Enclosed desorption electrospray ionization probes and method of use thereof

Desorption electrospray ionization sampling without damaging an in vivo tissue sample

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West Lafayette, IN, United States of America

Ziqing Lin