Chinese Academy of Sciences

Institute of Pharmacology and Toxicology Accademy of Military Medical Sciences P.l.a. China

Zihe Rao

Lili Wang

Song Li

Junhai Xiao

Hongying Liu

Liuhong Yun

Beifen Shen

Yingfang Liu

Aihua Nie

Hongxia Wang

Wuhong Pei

Songcheng Yang

Cuiling Shu

Present invention discloses the three-dimensional crystal structure of the N-terminus polypeptide of influenza virus polymerase subunit (PA_N of SEQ ID NO:7). PA_N of SEQ ID NO: 1 is residues 1&#x2014;50 to 150-300 of influenza virus polymerase subunit PA. In the three-dimensional structure, at least 40% of atoms show the same atomic coordinates, compared to that listed in Table 1. Namely, in the three-dimensional structure of influenza virus polymerase subunit PA_N of SEQ ID NO: 7, 40% of atomic coordinates on carbon skeleton of residues of influenza virus polymerase subunit PA_N of SEQ ID NO: 7, show less than or equal to 1.7 &#x212b; of average variance, compared to the atomic coordinates listed in Table 1. Present invention also discloses the expression, purification, crystallization methods, and three-dimensional crystal structure of 256 residues in the N-terminus of influenza virus polymerase subunit PA, and applications of the crystal structure of SEQ ID NO: 7 on drug screening and designing.

Crystal structure of amino terminal portion of influenza virus polymerase PA subunit and use thereof

This invention relates to substituted 6-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R, R, X, Y, and Z are as defined in the description; their preparation methods, compositions comprising the same, and their use as inhibitors of FK560 binding proteases activity for treating and preventing neurodegenerative diseases and other nerve disorders associated with nerve injuries or other related diseases 

Substituted 6-membered N-heterocyclic compounds and method for their use as neurological regulator

Growing community of inventors

Beijing, China

Zihe Rao