University of Connecticut

Musc Foundation for Research Development

Zihai Li

Pramod K Srivastava

Isolated or recombinant monoclonal antibodies that bind to GARP are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. Further provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of an anti-platelet agent and a T cell therapy.

Methods for treatment and diagnosis of cancer by targeting glycoprotein A repetitions predominant (GARP) and for providing effective immunotherapy alone or in combination

The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an &#x3b1;-2-macroglobulin (&#x3b1;2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an &#x3b1;2M preparation is administered in conjunction with a non-vaccine treatment modality for the treatment of cancer or infectious diseases. In the practice of the invention, a preparation comprising HSPs such as but not limited to, hsp70, hsp90 and gp96 alone or in combination with each other, noncovalently or covalently bound to antigenic molecules or &#x3b1;2M, noncovalently or covalently bound to antigenic molecules is administered in conjunction with a non-vaccine treatment modality.

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Mount Pleasant, SC, United States of America

Zihai Li