Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Theravir Management L.p.

Tel Aviv University

Zichria Zakay-Rones

Amos Panet

Charles S Irving

Eithan Galun

Ervin Weiss

Itzhak Ofek

Reuven Levy

Evgeniya Greenbaum

Yael Houri-Haddad

Arnold I Freeman

Linda Rasooly

The present invention discloses methods for inducing regression of a tumor in a subject by administering a pharmaceutical composition comprising a lentogenic strain of Newcastle disease virus (NDV). A preferred viral strain of NDV for inducing regression of a tumor in a subject is a clonal strain of NDV, the NDV HUJ. The methods of the present invention are particularly useful for inducing regression of tumors in patients unresponsive to conventional anti-cancer therapies.

Compositions of NDV and methods of use thereof for treatment of cancer

The present invention concerns the use as anti-viral agents of isolated fractions from berry juice of the plant genus. Two specific fractions are provided: (a) polymeric material having a molecular weight&#x2267;12,000; and (b) proanthocyanidins-containing fraction. Thus, the invention provides methods of treating a subject against a viral infection; the method comprises providing said subject with at least one of the above isolated fractions in an amount effective to prevent production of a viral infection in said subject. A specific and preferred viral infection according to the invention is an influenza virus infection.

Methods of treating viral infections using berry juice fractions

The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle Disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment of cancer by application of a clonal NDV strain to tumors. Another feature of the invention is the use of at least one isolated viral glycoprotein or a subunit or analog thereof or of an isolated polynucleotide encoding the same for the treatment of cancer.

Compositions and methods for treatment of cancer

The invention provides an influenza vaccine which comprises a heat inactivated whole virus influenza free of formalin and .beta.-propiolactone (BPL).

Influenza machine

Growing community of inventors

Jerusalem, Israel

Zichria Zakay-Rones