University of Southern California

Other

City of Hope

University of Delaware

Zibo Li

Peter Conti

Shuanglong Liu

Hancheng Cai

Dan Li

David A Horne

John E Shively

Joseph M Fox

Lin Li

Peter S Conti

Melissa Blackman

Matthew Hassink

Ramajeyam Selvaraj

Francois P Gabbai

Todd W Hudnall

Zhanhong Wu

Tzu-Pin Lin

Shuanlong Liu

Chiun-Wei Huang

This invention provides a class of dual mode imaging tracer capable of acting both as a fluorescent imaging tracer and a positron emission tomography imaging tracer. Tracers in accordance with this invention generally have a fluorescent core with a boron-fluoride element embedded therein. Exemplary embodiments of the tracer includeF-labeled BODIPY compounds and derivative thereof. Also provided are tracer kits containing a sterile formulation of a BODIPY dye either in a radio-labeled or pre-labeled state, and methods for imaging heart perfusion using theF-labeled dual mode tracers.

18F labeled BODIPY dye and its derivatives for PET imaging of heart perfusion and others

Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula 

Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same

A thio-selective radioactive labeling agent has the following general formula:*R-L-VS,

Vinylsulfone-based 18F-labeling compositions and methods and uses thereof

A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.

Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes

A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: 

Boron-based dual imaging probes, compositions and methods for rapid aqueous F-18 labeling, and imaging methods using same

This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled withCu orF. Also provided are methods for synthesizing the compounds, methods for derivatizing the compounds, and derivatives thereof.

Methods and compositions for positron emission tomography myocardial perfusion imaging

The present invention relates to methods of synthesizingF-FMAU. In particular,F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radiosynthesis module, which results in a reduction in synthesis time and simplifies reaction conditions. The one-pot reaction conditions are also suitable for the production of 5-substituted thymidine or cytidine analogs. The products from the one-pot reaction (e.g. the labeled thymidine or cytidine analogs) can be used as probes for imaging tumor proliferative activity. More specifically, these [F]-labeled thymidine or cytidine analogs can be used as a PET tracer for certain medical conditions, including, but not limited to, cancer disease, autoimmunity inflammation, and bone marrow transplant.

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Logan, UT, United States of America

Zibo Li