Other

Shanghai Curegene Pharmaceutical Co Ltd.

Smithkline Beecham Corporation

Cephalon, Inc.

Zi-Qiang Gu

Hao Wu

Kai Hou

Gongxin He

Yuanchao Zhang

John P Mallamo

Sankar Chatterjee

Kurt A Josef

Derek D Dunn

Robert A Daines

Kelvin C Sham

William D Kingsbury

Israel Pendrak

The present disclosure relates to compounds which exhibit activity in the inhibition of platelet aggregation as well as pharmaceutical compositions comprising these compounds and methods of treatment of vascular diseases by administration of these compounds or the pharmaceutical compositions.

Antiplatelet drugs and uses thereof

In various embodiments, provided herein are pamoate salts of monoamine Anti-Parkinsons disease agents including rotigotine, ropinirole, pramipexole, selegiline, rasagiline, and safinamide, pharmaceutical composition comprising the same, methods of preparing the same, and methods of using the same. For example, the pamoate salt herein can be characterized by a molar ratio of rotigotine, ropinirole, pramipexole, selegiline, rasagiline, or safinamide to pamoic acid of about 1:1 or about 2:1. The pamoate salt herein can also be crystalline including anhydrous, hydrate or solvate forms, or their polymorphs, or amorphous. The pamoate salts described herein can provide a long acting and/or extended release profile of the monoamine agents for the treatment of Parkinsons disease (PD). Thus, also provided herein are methods of preparing a long acting and/or extended release injectable formulation of the monoamine agents using their respective pamoate salts. And in some embodiments, provided herein are methods of treating a subject in need thereof comprising administering a pharmaceutical composition comprising a pamoate salt of rotigotine, ropinirole, pramipexole, selegiline, rasagiline, and/or safinamide.

Pamoate salt of monoamine anti-Parkinson's agents, method of preparation and use thereof

The composition containing a pamoate salt of donepezil, the method of preparation and the use thereof are disclosed.

Donezil pamoate, method of preparation and use thereof

Pamoate salts and methods of use

Memantine pamoate, method of preparation and use thereof

The present invention is directed to quinoline-containing .alpha.-ketoamide inhibitors of cysteine and serine proteases are disclosed. Methods for making these compounds, and methods for using the same are also disclosed.

Quinoline-containing .alpha.-ketoamide cysteine and serine protease

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Reston, VA, United States of America

Zi-Qiang Gu