Jiangnan University

Zhuying Zhang

Qian Zhao

Mingqing Chen

Dongjian Shi

Xiaojie Li

Chuanhao Cao

Jiali Shen

The invention discloses a preparation method of a catechol group modified biomacromolecular scaffold material, comprising: grafting a catechol-containing compound by amidation to obtain modified biomacromolecules; then, allowing dopamine to perform oxidized self-polymerization in a weakly alkaline buffer solution to form polydopamine (PDA) particles with a uniform particle size; next, forming a scaffold which has three cross-linking structures, namely modified biomacromolecules, modified biomacromolecules/PDA, and biomacromolecules/PDA, through interaction between catechol groups, interaction between catechol groups and PDA particles, and interaction between macromolecules and PDA particles in the modified macromolecules respectively; and cross-linking the scaffold with calcium ions, adipic dihydrazide or genipin to further adjust the degree of cross-linking and porosity of the scaffold. The prepared scaffold material has excellent biocompatibility and biodegradability, can promote cell adhesion, and has a wide application prospect in the field of tissue repair and regeneration.

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Jiangsu, China

Zhuying Zhang