Columbia University

Zhuoru Liu

Nicole Suciu-Foca

Chih-Chao Chang

George Vlad

Raffaello Cortesini

Adriana Ioana Colovai

The present invention relates to methods of using the expression of ILTL3 ligand or ILT3 on certain types of cancer cells as a diagnostic tool. Methods are provided for treating ILT3-ligand expressing cancers, such as T-cell acute lymphoblastic leukemia (T-cell acute lymphoblastic leukemia), for example by administering ILT3, the extracellular domain of ILT3 or ILT3Fc conjugated to a cytotoxic agent to kill the targeted cancer cell. Other methods are provided for treating cancers that express ILT3 on their surface, such as monocytic forms of AML, for example by administering anti-ILT3 antibodies conjugated to a cytotoxic agent.

Diagnosis and treatment of cancer expressing ILT3 or ILT3 ligand

This invention also provides a method of generating antigen specific human suppressor CD8+CD28&#x2212; T cells. This invention further provides a method of generating allopeptide antigen specific human suppressor CD8+CD28&#x2212; T cells. Methods of tent for reduction of risk of rejection of allografts and xenografts and autoimmune diseases using the human suppressor CD8+CD28&#x2212; T cells so produced are also provided, as are methods of preventing rejection and autoimmune diseases, and vaccines comprising the produced suppressor T cells. Methods of diagnosis to determine whether a level of immuno-suppressant therapy requires a reduction are provided.

Method of inducing anergic T helper cells

This invention provides a method of generating antigen specific allospecific human suppressor CD8&plus;CD28&minus; T cells. This invention also provides a method of generating xenospecific human suppressor CD8&plus;CD28&minus; T cells. This invention further provides a method of generating allopeptide antigen specific human suppressor CD8&plus;CD28&minus; T cells. Methods of treatment for reduction of risk of rejection of allografts and xenografts and autoimmune diseases using the human suppressor CD8&plus;CD28&minus; T cells so produced are also provides, as are methods of preventing rejection and autoimmune diseases, and vaccines comprising the produced suppressor T cells. Methods of diagnosis to determine whether a level of immuno-suppressant therapy requires a reduction are provided.

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New York, NY, United States of America

Zhuoru Liu