Chinese Academy of Medical Sciences

Zhuorong Li

Jian Xu

Rui Liu

Yang Chen

Yan Gao

Yanping Li

Jianrui Li

Xinbei Jiang

Ting Sun

Li Zeng

Jie Jin

Zonggen Peng

Jiandong Jiang

Shan Cen

Xuefu You

Jinhua Chen

Guanghui Zheng

Yuhuan Li

Peizhen Tao

Jian-Dong Jiang

Liyan Yu

Xinxin Hu

Yixuan Wang

Jiali Tan

Mimin Liu

Junxia Zhang

Xingyue Ji

Situ Xue

Along Cui

Qiyang He

A miRNA marker for the treatment and/or diagnosis of Alzheimer's disease (AD), and the miRNA marker is a miRNA23 cluster. The miRNA23 cluster is used in the diagnosis and treatment of AD. The expression of the miRNA23 cluster is detected using primers for the microRNA marker through AD model cells, AD model animals and natural aging animals, and blood of AD patients, and it is found that the expression of the miRNA23 cluster is significantly reduced during the progression of AD, which reduces neuronal apoptosis by inhibiting the GSK-3β-mediated tau protein phosphorylation. Therefore, the miRNA23 cluster can be used as a novel biomarker and therapeutic target for the early, non-invasive diagnosis and treatment of AD.

MiRNA marker for diagnosis and/or treatment of alzheimer's disease

Disclosed are a benzyl piperazine compound, a preparation method there for and an application thereof in an antivirus. The benzyl piperazine compound has a structure represented by the following general formula(I). It is proven by experiments that the benzyl piperazine compound not only has significant antiviral activity, but also has the advantages of low cytotoxicity, a high selectivity index and soon.

Phenylmethyl-piperazine derivatives and antiviral uses thereof

Provided are a new aromatic cyanogen compound and a preparation method thereof. The present invention also relates to the use of such compound in antiviral drugs, in particular the use thereof in anti-HCV drugs.

Type of antiviral compound

Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future. 

Cajanine structure analogous compound, preparation method and use

A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have the combined activity for the hA3G/Vif, but also have a function of inhibiting replication of viruses. The present invention provides the possible breakthrough progress for the problem of HIV drug resistance, thereby providing a novel clinical antiviral drug which has higher efficiency.

Group of amino substituted benzoyl derivatives and their preparation and their use

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Beijing, China

Zhuorong Li