Tianjin Institute of Pharmaceutical Research

Zhuanyou Zhao

Lida Tang

Weiting Wang

Peng Liu

Weiren Xu

Yuli Wang

Shijun Zhang

Yingmei Han

Guangping Xia

Naxia Zhao

Xiangwei Xu

Bing Yu

Wengong Xi

Wulin Liu

Chunhua Hao

Xiaoli Fu

Provided is a pharmaceutical composition comprising candesartan or ester thereof and chlorthalidone, and use thereof, wherein the weight ratio of candesartan or ester thereof to chlorthalidone is 5.3:1 to 1:6.25. The pharmaceutical composition has a synergistic antihypertensive effect, and can enhance the antihypertensive effect and extend duration of antihypertension.

Pharmaceutical composition comprising candesartan or ester thereof and chlortalidone, and use thereof

This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-&#x3b2;-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-&#x3b2;-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.

Cycloastragenol monoglucoside, preparation, pharmaceutical composition and application thereof

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Tianjin, China

Zhuanyou Zhao