Cas Lamvac (guangzhou) Biomedical Technology Co., Ltd.

Quaker Chemical Corporation

Cas Lamvac Biomedical Technology Co., Ltd.

Tao, Zhu

Ma, Jiangbo

Zhang, Yuming

Schellingerhout, Pieter

Zhu Tao

Xiaoping Chen

Ting Jiang

Li Qin

Yuming Zhang

Wen Hu

Jiangbo Ma

Yongchao Yao

Shuozhou Huang

Wenzhong Guo

Huihui Zhang

Jiaojiao Li

Yinbo Jiang

Yanli Gu

Pieter Schellingerhout

Provided are a chimeric antigen receptor and an application thereof; said chimeric antigen receptor contains a domain which identifies any one of, or a combination of at least two of, the malarial protein VAR2CSA, a protein tag on malarial protein VAR2CSA, or a compound capable of labeling the malarial protein VAR2CSA. The chimeric antigen receptor can identify the VAR2CSA protein or the recombinant protein (rVAR2) of any one of, or at least two of, the domains of the VAR2CSA protein which can bind to placental-like chondroitin sulfate A (pl-CSA). The VAR2CSA protein or rVAS2 protein is capable of targeting several different types of tumor cells by means of binding to the pl-CSA on the surface of the tumor cell.

Chimeric antigen receptor and application thereof

Growing community of inventors

Guangdong, China

Zhu Tao