Case Western Reserve University

Zhouping Wei

Anant Madabhushi

Satish E Viswanath

Pallavi Tiwari

Jacob Antunes

Charlems Alvarez Jimenez

The present disclosure, in some embodiments, relates to a non-transitory computer-readable medium storing computer-executable instructions. The computer readable medium is configured to cause a processor to access an image volume of a rectum comprising a rectal tumor. A forward mapping is generated based on non-rigidly registering a healthy rectal atlas to the image volume. The forward mapping is inverted to generate an inverse mapping from the image volume to the healthy rectal atlas. Based on the inverse mapping, a plurality of deformation vectors, associated with a deformation within a rectal wall of the rectum, are determined. Magnitude based deformation features and orientation based deformation features are computed from the plurality of deformation vectors. One or more of the magnitude based deformation features and one or more of the orientation based deformation features are utilized to determine a response of a patient to a chemoradiation treatment.

Structural rectal atlas deformation features for characterizing intra-wall and peri-wall chemoradiation response on magnetic resonance imaging (MRI)

Embodiments discussed herein facilitate determination of responsiveness to chemoradiation treatment in rectal cancer patients based on structural deformation features obtained from a pre- or post-treatment medical imaging. One example embodiment can perform operations comprising: accessing an image volume of a rectum comprising a rectal tumor; generating a forward mapping based on non-rigidly registering a healthy rectal atlas to the image volume; inverting the forward mapping to generate an inverse mapping from the image volume to the healthy rectal atlas; determining, based on the inverse mapping, an associated deformation magnitude for each voxel of a plurality of voxels associated with the rectum; computing one or more structural deformation features based on the associated deformation magnitudes for the plurality of voxels; and predicting via a classifier whether or not the rectal tumor will respond to the chemoradiation treatment based at least in part on the one or more structural deformation features.

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Cleveland, OH, United States of America

Zhouping Wei