Astrazeneca Ab

Astrazeneca Canada Inc.

Astra Pharma Inc.

Zhongyong Wei

Christopher Walpole

William Brown

Daniel Delorme

Edward Roberts

Hua Yang

Regis Dolaine

Compounds of formula I or pharmaceutically acceptable salts thereof Formula (I) wherein Ar, R, R, R, R, Rand X are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain 

Azaindole derivatives, preparations thereof, uses thereof and compositions containing them

Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

Compounds with analgesic effect

Compounds of general formula (I) wherein Ris selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl and triazolyl; where each Rphenyl ring and Rheteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C&#x2013;Calkyl, NO, CF, C&#x2013;Calkoxy, chloro, fluoro, bromo, and iodo. The substitutions on thephenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, inparticular in the management of pain.

4[piperidin-4-yliden-(3-carbamoylpheny)methyl]benzamide derivatives and their use for the treatment of pain spinal injuries or gastrointestinal disorders

Compounds of general formula I Ris selected from any one of phenyl, pyridinyl, pyrroloyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl and pyridine N-oxide; where each Rphenyl ring and Rheteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C&#x2013;Calkyl, NO, CF, C&#x2013;Calkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

4-(Phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestional disorders

Compounds of general formula I: Ris selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl and pyridine N-oxide; where each Rphenyl ring and Rheteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C&#x2013;C?6? alkyl, NO, CF, C&#x2013;Calkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders

 Compounds of general formula I[Chemical formula should be inserted here. Please see paper copy] Ris selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, and pyridine N-oxide; where each Rphenyl ring and Rheteroaromatic ring may optionally and independently be further substituted by 1,2 or 3 substituents selected from straight and branched C-Calkyl, NO, CF, C-Calkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

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Pierrefonds, Canada

Zhongyong Wei