Chiral Quest, Inc.

Zhongwei Tian

Jingyang Zhu

Wenge Li

Hui Lu

Sanhui Lin

Xinjun Liu

Xiaojuan Zhang

Zijun Liu

Fei Xiong

A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure: by asymmetrically hydrogenating a dehydro amino acid compound having the structure: in a suitable reaction media in the presence of a catalyst having a transition metal moiety complexed to a chiral phosphine ligand to prepare enantiomerically enriched cycloalkene substituted alanine compounds having the structure of Formula (IA) or (IB), which are key intermediates for the ACE inhibitors ramipril and perindolpril: 

Enantioselective process for cycloalkenyl &#x3b2;-substituted alanines

Growing community of inventors

Suzhou, China

Zhongwei Tian