Chinese Academy of Sciences

Zhongshun Yang

Yu Zhang

Ying Nan Li

Jianping Zuo

Junxia Wang

Yu Chen Zhou

Wei Tang

Ying Li

Jianxin Zhang

Yi Sui

Yu Zhou

Jinming Wu

Wenliang Zhou

Water-soluble artemisinin derivatives, their preparation methods, the pharmaceutical compositions containing the same derivatives and the use thereof are disclosed. The artemisinin derivatives have following formula I. It has been proved by pharmacological tests that these compounds and compositions have evident immuno-suppressive activities, and may be used in the preparation of novel immuno-suppressants for treating the diseases caused by hyperfunction of human immunity (e.g. the auto-immune diseases such as lupus erythematosus, rheumatoid arthritis, multiple sclerosis and the like), and for inhibiting the graft rejection after cell or organ transplantation. 

Water-soluble artemisinin derivatives, their preparation methods, the pharmaceutical compositions and the use thereof

The invention provides a type of artemisinin derivatives having following structure I, its preparation method and use, as well as a pharmaceutical composition containing such artemisinin derivatives and its use. The arteminsinin derivatives of the present invention and their pharmaceutical composition containing the artemisinin derivatives. have immunosuppressive activities and can be used more safely. The composition which comprises the artemisinin derivatives can be formulated into long-term dosage forms such as tablet, pellet and the like, and have wider productive and use value. 

Artemisinin (qinghaosu) derivatives, their preparation methods and their use, and pharmaceutical compositions containing the same

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Shanghai, China

Zhongshun Yang