Shanghai East Hospital

Zhongmin Liu

Qian Zhao

Feng Wan

Zuoren Yu

Yuanyi Peng

Guorong Li

Wenwen Jia

Jizhen Lu

Hongming Tang

The present disclosure relates to a micro magnetic-hydraulic suspension centrifugal blood pump, which is a pump and motor integrated device. The blood pump includes a pump housing, a rotor, an impeller, a servo motor, an inner magnetic core group, an outer magnetic ring group, a limiting device, and a suture snap ring device; the rotor and the impeller are seamlessly connected into a whole; the rotor is arranged in an inner pipe of the blood pump; the servo motor drives the rotor to drive the impeller to do work; the inner magnetic core group is arranged at a lower end inside the rotor; the outer magnetic ring group and a wrapping sleeve are upright in a pump cavity lower shell; an inner and outer magnetic combination can achieve a radial magnetic suspension effect of the impeller; a ceramic sheet and a ceramic cone form a temporary limiting bearing; a top end of a vane of the impeller is provided with an inclined surface; and the pump can generate hydraulic suspension during working. According to the technical solution of the present disclosure, the rotor impeller can work in a steady suspended state, which overcomes the friction effect of a mechanical bearing; the structures in the pump are simple and fluent, which can greatly reduce hemolysis and thromboembolic complications; the blood pump has a small volume and light weight, so that the invasiveness of operation is low, and the safety and the practicability can be improved.

Micro magnetic-hydraulic suspension centrifugal blood pump

A microRNA (miRNA) inhibitor, being able to form a stable DNA-RNA double-stranded structure with a miRNA. The double-stranded structure comprises: (i) a miRNA unit sequence, and (ii) an RNA zipper unit sequence. The 5'-end of the RNA zipper unit sequence is connected to the 5&#x2032;-end of the miRNA unit sequence. The 3&#x2032;-end of the RNA zipper unit sequence is connected to the 3&#x2032;-end of the miRNA unit sequence. The RNA zipper can connect the head of the miRNA molecule to the tail of the miRNA molecule to form a stable long-chain structure. The RNA zipper unit sequence contains 1-3 nucleotides not connected to the miRNA unit sequence. The DNA-RNA double-stranded structure can be used to inhibit biological activities of a miRNA unit, does not have biological toxicity, and has the advantages of high affinity, high specificity and high stability.

MicroRNA inhibitor

Growing community of inventors

Shanghai, China

Zhongmin Liu