Corium Corporation

Alza Corporation

Corium International, Inc.

Perfuse Therapeutics, Inc.

Corium Pharma Solutions, Inc.

Durect Corporation

Zhongli Ding

Parminder Singh

Guohua Chen

Esi Ghartey-Tagoe

Robert Wade Worsham

Danir F Bayramov

Lothar W Kleiner

David M Floyd

Catherine Manya Rohloff

Michael A DesJardin

Ashutosh Shastry

Doug Bourne

Sevgi Gurkan

Danir Bayramov

Stephen Andrew Berry

Latha Pisharody Narayanan

The present disclosure relates to the discovery that certain ocular diseases may be treated using Edonentan crystalline forms. Specific Edonentan crystalline form can be used alone or in combination with an intra-ocular pressure (TOP) reducing agent, a neuroprotective agent, or an anti-VEGF agent. Using Edonentan crystalline forms, alone or in combination with an additional agent, provides increased perfusion to the retina or reduced IOP in certain ocular diseases and reduces damage to retinal cells.

Compositions for treatment of ocular diseases

Microstructure arrays and methods for using and manufacturing the arrays are described.

Microarray for delivery of therapeutic agent and methods of use

Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described.

A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent.

Microstructure array, methods of making, and methods of use

A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic macromolecule and a stabilizing excipient. Described herein are microstructures having a proximal and distal layer, wherein the distal layer which contains the therapeutic molecule does not rely on the presence of a structure-forming polymer to impart the mechanical strength necessary to penetrate the skin. Methods of forming the array, and methods of using the array are contemplated.

Microarray with polymer-free microstructures, methods of making, and methods of use

Devices and methods for using and manufacturing microstructure arrays are described.

Microarray for delivery of therapeutic agent, methods of use, and methods of making

This invention relates to compositions and methods for preventing oxidation of beneficial agents.

Minimization of drug oxidation in drug irradiated excipients formulations

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Sunnyvale, CA, United States of America

Zhongli Ding