Avent, Inc.

Kimberly-clark Worldwide, Inc.

Zhongju Liu Zhao

Bhalchandra M Karandikar

Sunita J Macwana

Sophie Truc Lam

John P Gann

Carin J Berg

There is provided a method of producing a stabilized catalase enzyme. In the method, a substrate is thoroughly mixed with phosphate borate and catalase, rinsed with water and the solids dried. The dried solid may be mixed with polyvinyl alcohol and dried for further stabilization. The stabilized powder may be mixed with various skin solutions (lotions, ointments and the like). The catalase enzyme can catalyze the reaction of peroxide to oxygen.

Preparation of stabilized catalase enzymes using polyvinyl alcohol

There is provided a method of producing a stabilized microcrystalline cellulose powder containing catalase enzyme. In the method, cellulose is thoroughly mixed with phosphate borate and catalase, rinsed with water and a surfactant added. The stabilized powder may be mixed with various skin solutions (lotions, ointments and the like). The catalase enzyme can catalyze the reaction of peroxide to oxygen.

Preparation of stabilized catalase enzymes with a surfactant

There is provided a two part spray for the liberation and delivery of oxygen through the use of a first part that is a peroxide-containing solution and a second part that is a nanoparticle manganese dioxide catalyst. When the two parts are mixed together, the ensuing reaction results in the liberation of oxygen.

Two part oxygen generating system

There is provided on-demand, oxygen generating topical compositions having a built-in indicator specifically to indicate a color change upon the complete mixing of the oxygen precursor and catalyst. The first part of the composition contains a carrier and manganese dioxide (MnO2) nanoparticles. The second part of the composition comprises the oxygen precursor; hydrogen peroxide. When the two parts, one with manganese dioxide nanoparticles and exhibiting a characteristic color, (e.g. yellow brown) and the second part with hydrogen peroxide are mixed together, the color imparted by the manganese dioxide nanoparticles essentially disappears and the final composition (enriched with oxygen) either appears colorless or takes on the original color of the catalyst. Thus, the manganese dioxide catalyst nanoparticles themselves serve as the colorimetric indicator of peroxide decomposition to oxygen, precluding the need for an external colorant. Manganese dioxide particles that are not nanoparticles fail to exhibit this color changing phenomenon.

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Sherwood, OR, United States of America

Zhongju Liu Zhao