Sunshine Lake Pharma Co., Ltd.

North & South Brother Pharmacy Investment Company Limited

Yichang Hec Changjiang Pharmaceutical Co., Ltd.

Zhonghua Luo

Zhongqing Wang

Bifei He

Lei Chen

Jiebin Zeng

Xiaodong Han

Yuping Fan

Guodong Sun

Guangyuan Liu

Shun Li

Qian Wang

Xin Lei

Jinchao Xu

Huixiong Lu

Huiqing Ye

Dongming Li

Shouhua Zhang

The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril.

Sacubitril intermediate and preparation method thereof

The invention relates to a diaryl thioether piperazine compound, a preparation method and use thereof. Specifically, the compound is a compound of Formula (I), wherein HX is Cfatty acid or pamoic acid. 

Diaryl thioether piperazine compounds, preparation methods and uses thereof

Provided are compounds of formula (I), or a stereoisomer, mixture of stereoisomers, deuterated analog, tautomer, solvate or pharmaceutically acceptable salt thereof, compositions, method of making and uses thereof. 

Memantine compounds and their preparation and uses thereof

Provided herein are crystalline forms of (((((1r, 3R, 5S, 7r)-3, 5-dimethyladamantan-1-yl)carbamoyl) oxy) methyl benzoate (Compound (I)): Also provided are compositions comprising the crystalline forms of Compound (I), processes of manufacture and methods of using the crystalline forms of Compound (I). 

Solid forms of an adamantyl compound, compositions and uses thereof

The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril. The method disclosed herein has advantages of easily obtained raw materials, simple preparation process, low cost, environment friendly, and etc., which is very suitable for industrial production.

The present invention relates to the field of pharmaceutical chemistry, specifically relates to a statin intermediate having formula I and preparation thereof. The advantages of the method used to prepare the chiral sulfone intermediate having formula I are that a fluorophore is introduced at the beginning of the synthesis, and the intermediates are mostly solid, which enables quality control to be easily carried out.

Intermediate of statin drugs and preparation thereof

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Dongguan, China

Zhonghua Luo