Ngm Biopharmaceuticals, Inc.

Zhonghao Liu

Yan Wang

Wenwu Zhai

Yiyuan Yin

Xunshan Ding

Wenyan Shen

Hugo Matern

Jie Tang

Dana Yen Mei Duey

Chun Chu

Jared Martin Higbee

The present disclosure provides methods comprising a glucagon receptor antagonist in combination with an immunotherapeutic agent for treatment of disease.

Combination therapy with a glucagon receptor (GCGR) antibody and an anti-CD3 antibody

The present disclosure provides binding agents, such as antibodies (including single chain variable fragments), that specifically bind complement component C3, including human C3, compositions comprising same, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising same.

C3-binding agents and methods of use thereof

The present disclosure provides binding proteins, such as antibodies, that bind glucagon receptors, including a human glucagon receptor, and methods of their use.

Methods of reducing or lowering blood glucose levels in a human subject by administering an antibody that specifically binds human glucagon receptor

The present disclosure provides binding agents, such as antibodies, that specifically bind Angiopoietin-like protein 8 (ANGPTL8), including human ANGPTL8, and methods of their use.

Methods of lowering triglyceride levels with an ANGPTL8-binding antibody or antigen-binding fragment thereof

Anti-C3 antibodies

Antibodies which bind human glucagon receptor

Method of treating type I diabetes by administering a combination of a glucagon receptor antagonist and an anti-CD3 antibody

ANGPTL8-binding agents and methods of use thereof

Methods and compositions for reducing one or more of triglyceride levels, total cholesterol levels and LDL cholesterol levels in a subject are provided. The methods include administering a fragment of ANGPTL8 to a subject having or at risk of developing elevated triglyceride levels, elevated total cholesterol levels and/or elevated LDL cholesterol levels.

Angiopoietin-like protein 8 polypeptide fragments and compositions thereof

Methods for treatment of conditions associated with elevated triglycerides with an ANGPTL8 polypeptide fragment

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Redwood City, CA, United States of America

Zhonghao Liu