The General Hospital Corporation

Waterstone Pharmaceuticals(wuhan) Co., Ltd.

Waterstone Pharmaceuticals Co., Ltd.

Zhongcong Xie

Jian Cui

Faming Zhang

Minglong Hu

Yao Yu

The present invention relates to a method of treating, preventing, or lessening postoperative cognitive dysfunction (POCD) in a subject in need thereof, the method comprising the step of administering to the subject a therapeutically effective amount of a compound of Formula I or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof,

WS-635 uses thereof in medicine

A device for selectively providing an odor-rich environment includes a housing and a cover. The housing includes a central cavity and a plurality of chambers configured to store a predefined fragrance therein and having a respective outlet formed on an outer wall of the housing. The cover includes an exterior surface having at least one vent formed on the exterior surface. The exterior surface includes an interior sidewall and an exterior sidewall forming an inner chamber that slidably engages the housing such that the cover is configured to move between an open position and a closed position. Responsive to the cover being in the open position, the at least one vent is generally adjacent to the outlet of at least one of the plurality of chambers of the housing. The odor-rich environment can assist in preventing and/or treating postoperative delirium (POD) postoperative cognitive dysfunction (POCD), and/or pain in a subject.

Devices and methods for selectively providing an odor-rich environment

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Andover, MA, United States of America

Zhongcong Xie