Guilford Pharmaceuticals, Inc.

Other

Johns Hopkins University

Eisai Inc.

Zhong Zhao

James Perry English

Kam W Leong

Hai-Quan Mao

Wenbin Dang

David Peter Nowotnik

Keith Edward Branham

Donna Hall

Mahesh V Chaubal

Irina Nikolaevna Kadiyala

Hungnan Lo

Reuben Land

Deborah Barnette

Wensin Dang

Doug Mink

The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.

Phosphorus-containing compounds with polymeric chains, and methods of making and using the same

Phosphorous-containing compounds with polymeric chains, and methods of making and using the same

Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same

Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same

Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles and methods of using the same

The present invention provides improved processes for purifying polymer preparations by removing contaminants, such as metal contaminants. The present invention also provides improved processes for producing phosphopolymers, which can yield improved polymers in terms of molecular weight, homogeneity, consistency and purity. Polymers and polymer preparations also are provided. The present invention is time, labor and energy efficient, and thus marks an improvement over past approaches.

Polymers and polymerization processes

Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same

Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same

Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I:

Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is --O-- or --NR'--, where R' is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M.sub.1 and M.sub.2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is --O--, --S-- or --NR'--, where R' is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

Biodegradable polymers chain-extended by phosphates, compositions,

A medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I below: ##STR1## wherein R is a divalent organic moiety; R' is an aliphatic, aromatic, or heterocyclic residue; x is .gtoreq.1; and n is 3-7,500, and where the biodegradable terephthalate copolymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. In addition, compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.

Biodegradable terephthalate polyester-poly (phosphonate) compositions,

A process for making a high molecular weight poly(phosphoester) comprising the recurring monomeric units: ##STR1## wherein X is --O-- or --NR'--, where R' is H or alkyl; L is a divalent organic moiety, with the proviso that L cannot have the formula ##STR2## R' is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic, or heterocycloxy; and n is from about 25 to 2000, is described. The process comprises the steps of:

Solution polymerization of high molecular weight poly(phosphoesters) in

A process for making a phosphoester polymer comprising the recurring monomeric units of formula I: ##STR1## wherein: X is --O-- or --NR'--, where R' is H or alkyl;

Two-stage solution polymerization of high molecular weight

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Ellicott City, MD, United States of America

Zhong Zhao