Wayne State University

Board of Sup. of Lsu and Agr. & Mechanical College

Louisiana State University and Agricultural & Mechanical College

Zhong Q Wang

Nikhil V Dhurandhar

Thomas C Holland

Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis. Ad-36 E4 orf 1 protein can be used to increase insulin sensitivity and ameliorate diabetes. Additionally, drugs that mimic the action of Ad-36 E4 orf 1 protein could be found. Ad-36 E4 orf 1 could also be used to increase fat cells in lipodystrophy. We have also discovered that Ad-36 infection in human skeletal muscle cells increased differentiation and insulin independent glucose uptake. It is expected that infection with Ad-36 E4 orf 1 gene will also cause these effects.

Growing community of inventors

Baton Rouge, LA, United States of America

Zhong Q Wang