The Ohio State University

Adaptive Sensory Technology, Inc.

Arizona State University

The University of North Carolina at Chapel Hill

The Penn State Research Foundation

University of San Francisco

Chinese Academy of Sciences

New York University

Yale University

The Schepens Eye Research Institute, Inc.

Research Institute at Nationwide Children's Hospital

Beijing Juehua Medical Technology Co., Ltd.

Zhong-Lin Lu

Luis A Lesmes

Jinghua Wang

James Wilson

Yalin Wang

Shankar Bhamidi

Matthew Denny

Skyler Cranmer

Paul Stillman

Bruce Desmarais

Robert Todd Constable

Peter Bex

Michael Dorr

Jiawei Zhou

Deyue Yu

Jongsoo Baek

Duyan Ta

Yukai Zhao

Nehal Parikh

Yanshuai Tu

Lili He

Chang-Bing Huang

Pengjing Xu

Wuli Jia

A sensory mapping method for a human brain is disclosed. The method includes the steps of flattening the cortical surface of the human brain, projecting functional imaging data onto the flattened surface, smoothing the functional imaging data, generating a sensory map, registering sensory maps across individuals and analyzing the maps in the common space. The flattening utilizes a conformal parametrization method. The smoothing utilizes a topological smoothing method that utilizes a diffeomorphic smoother. The registering is diffeomorphic. The sensory mapping method may further include a step of processing the functional imaging data to produce topological results.

Methods and systems for precise quantification of human sensory cortical areas

The present disclosure relates to systems and methods for characterizing a behavior change of a process. A behavior model that can include a set of behavior parameters can be generated based on behavior data characterizing a prior behavior change of a process. A stimulus parameter for a performance test can be determined based on the set of behavior parameters. An application of the performance test to the process can be controlled based on the stimulus parameter to provide a measure of behavior change of the process. Response data characterizing one or more responses associated with the process during the performance test can be received. The set of behavior parameters can be updated based on the response data to update the behavior model characterizing the behavior change of the process. In some examples, the behavior model can be evaluated to improve or affect a future behavior performance of the process.

Systems and methods for measuring behavior changes of processes

Method and systems provide a tool to quantify sensory maps of the brain. Cortical surfaces are conformally mapped to a topological disk where local geometry structures are well preserved. Retinotopy data are smoothed on the disk domain to generate a curve that best fits the retinotopy data and eliminates noisy outliers. A Beltrami coefficient map is obtained, which provides an intrinsic conformality measure that is sensitive to local changes on the surface of interest. The Beltrami coefficient map represents a function where the input domain is locations in the visual field and the output is a complex distortion measure at these locations. This function is also invertible. Given the boundaries and the Beltrami map of a flattened cortical region, a corresponding visual field can be reconstructed. The Beltrami coefficient map allows visualization and comparison of retinotopic map properties across subjects in the common visual field space.

Apparatus and method for quantification of the mapping of the sensory areas of the brain

Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.

Systems and methods for modeling neural architecture

A system can include a non-transitory memory to store machine readable instructions and data, and a processor to access the non-transitory memory and execute the machine-readable instructions. The machine-readable instruction can include a global module that can be programmed to generate a visual field map (VFM) model that can include a set of visual function map parameters for an entire visual field for a subject. The global module can be programmed to update the set of visual function map parameters corresponding to updating a shape of the VFM based on subject response data generated during each administration of a vision test to a subject.

Systems and methods for measuring visual function maps

The invention provides a method of generating an adaptive partial report for an observer with an apparatus comprising a display, a user interface, and a processor. The apparatus can be a computer system or an electronic device, for example. The method includes the processor characterizing an iconic memory decay function for the observer. The characterization includes determining a prior for a plurality of parameters. The method further includes the processor determining a first stimulus for a first trial based on the prior for the plurality of parameters, the display generating the stimulus for viewing by the observer, the user interface receiving input for the first trial and in response to the stimulus, the processor revising respective parameter values for the parameters based on the received input, and the processor determining a new stimulus for a next trial based on the revised parameter values.

Method of generating an adaptive partial report and apparatus for implementing the same

Techniques for optimizing a magnetic resonance imaging (MRI) protocols are described herein. An example method can include receiving one or more MRI scanner settings for an imaging sequence; selecting at least one objective function from a plurality of objective functions; selecting an acquisition train length; selecting a k-space strategy; selecting one or more imaging parameters; and acquiring a magnetic resonance (MR) image using at least one of an optimized k-space strategy, an optimized acquisition train length, or optimized imaging parameters.

Methods and devices for optimizing magnetic resonance imaging protocols

Systems and methods for using an interocular inhibition procedure (IIP) for discriminating between anisometropic amblyopia and myopia, two disorders commonly confused in visual examination without proper optical correction. Opaque and translucent patching are positioned over the fellow (or untested) eye resulting in different contrast sensitivities in the amblyopic (or tested) eye. A pinhole aperture may be used for identifying amblyopia and myopia/hyperopia.

Method of identifying and eye disorder of an observer and apparatus for implementing the same

Methods for correcting inhomogeneities of magnetic resonance (MR) images and for evaluating the performance of the inhomogeneity correction. The contribution of both transmit field and receiver sensitivity to signal inhomogeneity have been separately considered and quantified. As a result, their negative contributions can be fully corrected. The correction method can greatly enhance the accuracy and precision of MRI techniques and improve the detection sensitivity of pathophysiological changes. The performance of signal inhomogeneity correction methods has been evaluated and confirmed using phantom and in vivo human brain experiments. The present methodologies are readily applicable to correct signal intensity inhomogeneity artifacts produced in different imaging modalities, such as computer tomography, X-ray, ultrasound, and transmission electron microscopy.

Signal inhomogeneity correction and performance evaluation apparatus

Data is received characterizing a result of a first visual sensitivity test assessing capacity to detect spatial form across one or more different target sizes, and different contrasts. Using the received data, one or more first parameters defining a first estimated visual sensitivity for a first range of contrasts and a second range of spatial frequencies is determined. One or more second parameters defining a second estimated visual sensitivity for a third range of contrasts and a fourth range of spatial frequencies is determined using the one or more first parameters and a statistical inference by at least presenting a first visual stimulus, receiving a response, and determining a second visual stimulus based at least on the response and at least a rule. The one or more second parameters is provided. Related apparatus, systems, techniques and articles are also described.

Rapid measurement of visual sensitivity

MRI techniques are widely and successfully applied in medicine and biophysics because MRI provides good contrast between different soft tissues without ionizing radiation. MRI protocols are optimized in four aspects: imaging parameters, k-space strategies, RF system calibration and contrast inhomogeneity correction. The signal intensities of normal and disease tissues are simulated, for example, using Bloch equations for an imaging sequence with tissue MR parameters. The relationships between imaging parameters and tissue contrasts are calculated using the numerically simulated signal intensities. The optimal imaging parameters and/or k-space strategies are determined to maximize image contrast and minimize artifacts with acceptable spatial-temporal resolution based on characterization of the imaging hardware. The RF system is optionally calibrated to improve the accuracy of the imaging parameters and reduce inter-scanner variability. Additionally, contrast-to-noise inhomogeneity caused by transmit field and receive sensitivity is optionally corrected by optimal flip angle and measured receiver sensitivity.

Methods and devices for optimization of magnetic resonance imaging protocols

A method for estimating receiver coil sensitivity in a magnetic resonance (MR) system having a plurality of coils in a coil array including a reference coil, including steps of estimating receiver coil sensitivity in each of the plurality of coils in the coil array of the MR system using one of an electromagnetic field method, a bias field method, and a uniform transmit field method. Each of the plurality of coils in the coil array includes one or more of a surface coil, a volume coil, a set of coil arrays, or an antenna element of a coil array. The method further includes steps of obtaining a reference image using the reference coil; generating a measured sensitivity map using the reference coil; and for each of the plurality of coils of the coil array, calculating a receiver coil sensitivity map.

Methods and apparatus for accurate characterization of signal coil receiver sensitivity in magnetic resonance imaging (MRI)

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Dublin, OH, United States of America

Zhong-Lin Lu