Institute of Radiation Medicine, Academy of Military Medical Sciences, Pla.

Beijing Increase Innovative Drug Co., Ltd

Zhiyun Kang

Jun Li

Jie Hu

Hongwu Zhang

Wenhui Li

Fang Wang

Zuze Wu

Zhongxiong Tang

Chunmei Xue

Zhenzhen Wu

Baoxian Zhang

Yanwei Song

Anping Chen

Zhuangrong Sun

Hengchun Ren

Provided are a Rho kinase inhibitor, a method for preparing same and the uses thereof. The Rho kinase inhibitor designates a compound of Formula I, a stereoisomer thereof or pharmaceutically acceptable salt thereof. The Rho kinase inhibitor promotes endothelial cells and endothelin expression, prostenin expression, and vascular factors NO synthesis and secretion, has a promoting effect on proprostin expression independently of the doses used, shows lower toxicity, while being safer.

Rho kinase inhibitor, method for preparing same and uses thereof

The present invention relates to cis-1,2-substituted stilbene derivatives, or their pharmaceutically acceptable salts, glucosides or solvates, a pharmaceutical composition comprising the compound, and use of said compound for preparation of a drug for treatment and/or prevention of diabetes or improvement of diabetic complications.

Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes

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Beijing, China

Zhiyun Kang