Takeda Pharmaceutical Company Limited

The Scripps Research Institute

Takeda San Diego, Inc.

Takeda Pharmaceutical Company Limied

Sironax Ltd.

Zhiyuan Zhang

Jeffrey Alan Stafford

Stephen L Gwaltney

Jun Feng

Michael Brennan Wallace

Paul Isbester

Grant Jackson Palmer

Bruce Joseph Elder

Luckner Gerard Ulysse

Jonathon Stuart Salsbury

Stephen W Kaldor

Betty Lam

Chi-Huey Wong

Qing Dong

Xiao-Yi Xiao

Timor Baasov

Nicholas Scorah

Bheema Rao Paraselli

David J Hosfield

Lily Kwok

Zhe Li

John David Lawson

Sheldon Cao

Jerome C Bressi

Sripathy Venkatraman

Bingidimi Itute Mobele

Paul R Brodfuehrer

Ian Ollmann

Xin-Shan Ye

Yaning Su

Mallareddy Komandla

Richard S Fornicola

Shaosong Chu

Maxwell M Reeve

Zhaolan Zhang

Yanping Xu

Philip Erickson

Sanjib Das

Jonathan S Salsbury

Paul R Brodfuahrer

Philip B Kisanga

Paul K Isbester

Sheldon X Cao

Bheema R Paraselli

Stephen L Ii Gwaltney

Luckner G c/o Albany Molecular Research Inc Ulysee

Jonathon S c/o Albany Molecular Research Inc Salsbury

Grant J c/o Albany Molecular Research Inc Palmer

Bruce J c/o Albany Molecular Research Inc Elder

Paul K c/o Albany Molecular Research Inc Isbester

Ii Stephen L Gwaltney

Provided are piperazine cyclic urea compounds that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), pharmaceutically acceptable salts, hydrates and stereoisomers thereof. Provided are also pharmaceutical compositions, methods of making, and methods of use which include treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Piperazine cyclic ureas

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR; Qand Qare each independently selected from the group consisting of CO, SO, SO, and C&#x2550;NR; and each L, X, R, R, and Rare as defined herein.

Dipeptidyl peptidase inhibitors

Compounds, pharmaceutical compositions and kits are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Kinase inhibitors

Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase. 

Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.

cMET inhibitors

Disclosed are compounds, pharmaceutical compositions, kits, articles of manufacture, methods of using, and methods of preparing compounds having the formula: wherein the variables are as defined herein. The disclosed compounds are inhibitors of Renin.

Renin inhibitors

The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9 proteases activities and consist of the formula:&#x2014;wherein the variables are as defined herein. 

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO, or C&#x2550;NR, and L, X, Z, Rand Rare as defined herein.

Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.

Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein Ris amino (C)alkyl, hetero(C)cycloakyl, hetero(C)bicycloaryl, heteroaryl, or cyano; and W, X, Y, Z, R, Rand Rare as defined herein.

Growing community of inventors

San Diego, CA, United States of America

Zhiyuan Zhang