Xiamen University

Hongyun Biotech Co., Ltd.

Zhiyu Hu

Xianming Deng

Ting Zhang

Zhou Deng

Xihuan Sun

Qingyan Xu

Li Li

Wei Peng Huang

Shuang Liu

Xiaoyang Li

Chao Dong

Jingfang Zhang

Xiaoxing Huang

Yan Liu

Baoding Zhang

Zhixiang He

Zaiyou Yang

Jiaji Zhong

Yun Chen

Yunzhan Li

Yue Lu

Zhongji Zhuang

Xinrui Wu

Wei Huang

Qiaofeng Kang

Yanru Yang

A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof

The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification. 

Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof

The present invention relates to thienopyrimidine compound, preparation method thereof, pharmaceutical composition and use thereof, and in particular to a type of compounds having ALK and/or c-Met selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with anaplastic lymphoma kinase in vivo, and in the manufacture of a medicament for preventing or treating a disease associated with angiogenesis or cancer metastasis, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis. 

Thienopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof

The present invention relates to a compound of formula I, a stereoisomer, a prodrug, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, and a process for preparing the same, a pharmaceutical composition comprising the same, and use of the compound in the preparation of medicine preventing and treating tumors, wherein the substituents are as defined in the specification. 

Pyrimidopyrrole compounds, method for preparing the same, pharmaceutical compositions comprising the same and uses thereof

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Xiamen, China

Zhiyu Hu