Wigen Biomedicine Technology (shanghai) Co., Ltd.

Hangzhou Guanyu Bio-medical Co., Ltd.

Zhiyi Yao

Hualiang Jiang

Kaixian Chen

Yuli Xie

Cheng Luo

Yuanyuan Zhang

Liyan Yue

Wei Wan

Bing Zhou

Sheng Jiang

Yiwu Yao

Yatao Qiu

Changyin Lu

Kun Su

Bidong Zhang

Xiaoming Yao

It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators. 

Compound used as autophagy regulator, and preparation method therefor and uses thereof

The present invention provides an isoindolone-imide ring-1,3-dione-2-ene compound, and a preparation method, a pharmaceutical composition and use thereof. Specifically, the present invention provides a compound of Formula (I) below or a pharmaceutically acceptable salt thereof, wherein Ar is an isoindolinone-imide group represented by Formula (II), L is absent or is a divalent, trivalent or tetravalent linking group, and X is a group represented by Formula (III). Definitions of the other groups are as described in the specification. The compound of Formula (I) is an autophagy modulators, particularly a mammalian ATG8 homolog modulator. 

Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof

The present invention relates to a cyclic peptide compound, and a preparation method, pharmaceutical composition and use thereof. In particular, the cyclic peptide compound of the present invention has a structure as shown by general formula (I). The compound of general formula (I), and isomers, racemates, pharmaceutically acceptable salts, crystalline hydrates, solvates or mixtures thereof have a use in the preparation of medicaments for preventing or treating mammalian diseases associated with histone deacetylase dysregulations. 

Cyclic peptide compound, and preparation method, pharmaceutical composition and use thereof

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Shanghai, China

Zhiyi Yao