Atyr Pharma, Inc.

Zhiwen Xu

David J King

Luke Burman

Leslie Ann Greene

Ryan Andrew Adams

Ann Menefee

Kaitlyn Rauch

Liting Zhai

Yee Ting (Esther) Chong

Leslie Nangle Greene

Yanyan Geng

Yeeting Chong

Kristina Hamel

Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.

Compositions comprising anti-NRP2 antibodies

Provided are antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, for example, human histidyl-tRNA synthetase (HRS), and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.

Compositions and methods comprising anti-NRP2 antibodies

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La Jolla, CA, United States of America

Zhiwen Xu