Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Zhisen Zhang

Hong Shen

Taishan Hu

Buyu Kou

Wei Zhu

Xianfeng Lin

Weixing Zhang

Lei Guo

Mingwei Zhou

Shixiang Yan

Houguang Shi

Haixia Liu

Xingchun Han

Buelent Kocer

Guolong Wu

Yimin Hu

Gangqin Li

Zhiwei Zhang

Fabian Dey

Yongfu Liu

Ge Zou

Hongtao Xu

Jianguo Chen

Xiaoqing Wang

Yafei Liu

Zheng Zhou

Lue Dai

Linuo Zhu

The present invention relates to compounds of formula (I), wherein Rand Rand n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

Hydropyrazino[1,2-d][1,4]diazepine compounds for the treatment of autoimmune disease

The present invention relates to compounds of formula (I), wherein R, R, Y and A are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Spiro (isobenzofuranazetidine) compounds for the treatment of autoimmune disease

The invention provides novel compounds having the general formula: wherein R, R, R, R, R, R, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.

6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

The present invention relates to compounds of formula (I), ab (I), wherein R1 to R3 and L are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Heteroaryl heterocyclyl compounds for the treatment of autoimmune disease

The present invention relates to compounds of the formula (I), 

Methods of synthesizing pyrazine compounds

Pyrazolopyrazine and triazolopyrazine compounds for the treatment of infectious diseases

Carboxy tetrahydropyrazolopyrazine compounds for the treatment of infectious diseases

Pyrazine compounds for the treatment of infectious diseases

The invention provides novel compounds having the general formula: wherein R, R, Rand Rare as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.

6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

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Shanghai, China

Zhisen Zhang