Yaopharma Co., Ltd.

Sichuan University

Zhirong Zhang

Yan Zhang

Xu Song

Jianbo Li

Xiaoqing Bai

Ling Zhang

Meiling Zhou

Tao Gong

Tijia Chen

Yao Fu

Xun Sun

Bei Zhang

An organic amine ester derivative drug of 2-(&#x3b1;-hydroxypentyl)benzoic acid and a preparation method thereof and an use thereof are disclosed. The present disclosure particularly relates to a compound having the general formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable formulation prepared from the compound or the pharmaceutically acceptable salt thereof. The compound having the general formula I or the pharmaceutically acceptable salt thereof has in vitro a good solubility and a low hygroscopicity, and has in vivo a bioavailability and a brain aggregation concentration that are significantly greater than those of the original medicine butyphthalide and/or an improving drug efficacy. The use of the compound in the preparation of a drug for preventing and/or treating heart and cerebral ischemic diseases, a drug for preventing and/or treating heart and cerebral artery occlusion diseases, an anti-parkinsonian drug and an anti-senile-dementia drug is also disclosed. 

Organic amine ester derivative drug of 2-(&#x3b1;-hydroxypentyl)benzoic acid

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable formulation prepared using the compound and the salt. The compound represented by formula (I) or the pharmaceutically acceptable salt exhibits significantly higher buildup and concentration in the lungs compared to other tissues, a longer dwell time in the lungs, and/or elevated pharmaceutical efficacy. 

Podophyllotoxin derivative with 4-position nitrogen substitution and preparation method and application thereof

Provided is a nRGD polypeptide formed by connecting alanine-alanine-asparagine (AAN) and a polypeptide containing arginine-glycine-aspartic acid (RGD), wherein the nRGD polypeptide can target tumor vessels, tumor cells and tumor-associated macrophages, and mediate the targeted delivery of tumors.

Type polypeptide targeting tumours

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Sichuan, China

Zhirong Zhang