Tencent Technology (shenzhen) Company Limited

Shenzhen University

Sichuan University

Fapon Biotech Inc.

Byd Company Limited

Shenzhen Jisu Technology Co., Ltd

Tencent Technology Company Limited

Zhiqiang He

Ling Chen

Mingzhong Gao

Heping Xie

Cong Li

Liang Ma

Jun Guo

Chunhua Luo

Zetian Zhang

Zhilong Zhang

Yiqiang Lu

Peng Cui

Yuan Meng

Bo Yu

Dongmei Zhong

Mingqing Yang

Ru Zhang

Jianan Li

Xuan Yu

Jianbo Zhu

Cunbao Li

Jing Zhou

Zhiyi Liao

Cheng Guo

Le Zhao

Yunqi Hu

Guikang Liu

Qi Li

Tao Lin

Yuedong Weng

Jianjun Hu

Nianhan Wu

Chenghang Fu

Xin Hui Zhang

Yong Fan

Wen Zhang

Yi Liu

Yu Wei Chen

Wei Li

Yun Yang

Wei Zheng

Guanzheng Zheng

Yuan Yuan

Xiaohui Zheng

Yu Tian

Cheng Ye

Yong Zhu

Sheng Huang

Pengfei Huang

Sheng Che Chen

Shuiyong Yuan

Xiang Zhu

Xiaohui Chen

Ran Ding

Xiangbiao Jiang

Xiejuan Liao

Lingyun Fan

Kan Liao

Helin Qiu

Xiaofei Cheng

Wuming Yin

Yancen Lin

Xiongfei Wu

Jize Yang

Ming Han

Caiming Fu

Fajiang He

Hui You

Guanyan Xu

Qingxin Chen

Linbo Zhang

Xiaojing Tu

Yuankun Zheng

Mingang Huang

Yihua Jin

Provided is an isolated binding protein including an antigen binding domain binding to an NS1 protein, and comprising specific heavy chain CDR and light chain CDR. The binding protein can specifically identify and bind to NS1, and has relatively high sensitivity and specificity, so as to detect dengue virus. Moreover, the binding protein does not need to be produced by injecting hybridoma cells into mouse peritoneal cavity, while simplifying production, thus stabilizing antibody functionality.

NS1-binding protein

The present invention provides an isolated binding protein comprising a cTnI antigen binding domain. The antigen binding domain comprises at least one complementarity determining region selected from amino acid sequences defined herein, or has sequence identity of at least 80% to the complementarity determining region of said amino acid sequence and an affinity of K≤1.41×10mol/L to cTnI. The binding protein can be used for detection of cTnI protein.

Recombinant antibody against human cardiac troponin I

Umbrella handle assembly

Provided is an isolated binding protein including an antigen-binding domain that binds to NS1 protein. The isolated binding protein includes specific heavy chain CDRs and light chain CDRs. The binding protein can specifically recognize and bind to NS1, and has relatively high sensitivity and specificity, thereby achieving the detection of dengue virus. Moreover, the binding protein is not required to be produced by inducing hybridoma cells in mouse abdominal cavity, and thus it is simple in production and has more stable antibody function.

Binding protein of NS1 protein

Provided is an isolated binding protein including an antigen binding domain binding to an NS1 protein, and including specific heavy chain CDR and light chain CDR. The binding protein can specifically identify and bind to NS1, and has relatively high sensitivity and specificity, so as to detect dengue vims. Moreover, the binding protein does not need to be produced by injecting hybridoma cells into mouse peritoneal cavity, while simplifying production, thus stabilizing antibody functionality.

Disclosed is a magnetic pressure retaining control device, which comprises: a valve seat, a magnetic valve cover, and a trigger magnetic member for repelling the magnetic valve cover; the magnetic valve cover and an open end of the valve seat are movably connected; when the magnetic valve cover is in an open state, the trigger magnetic member is opposite to an end surface of the magnetic valve cover away from an inside of the valve seat. A cylindrical magnet is also arranged in the valve seat. By the magnetic between the trigger magnet and the magnetic valve cover, and the magnetic between the magnetic valve cover and the valve seat, a reliable guarantee for the closure between the magnetic valve cover and the valve seat is provided. The valve seat and the valve cover are tightly closed under different conditions.

Magnetic pressure retaining control device

An internal blowout-prevention gas-retaining connector has a body mounted at the bottom of a drill pipe. The body includes a valve pipe section and a connecting pipe section arranged from top to bottom. The bottom of the valve pipe section is inserted into the top of the connecting pipe section. The blowout-prevention valve seat is provided at a bottom end of the valve pipe section while a blowout-prevention valve bonnet is provided on a bottom surface of the valve pipe section. The edge of the blowout-prevention valve bonnet is rotatably connected to a bottom surface edge of the valve pipe section. A torsion spring is provided on a bottom surface of the blowout-prevention valve bonnet. One end of the torsion spring is connected to the bottom surface of the blowout-prevention valve bonnet while the other end is connected to the inner wall of the connecting pipe section.

Internal blowout-prevention gas-retaining connector for mine

A simulation device for magnetic closing of flap valve is disclosed, which includes a worktable, a driving mechanism for driving the worktable to rotate, a valve seat, a magnetic valve cover movably connected with the valve seat, a first magnet for repelling the magnetic valve cover, a cylinder, a lifting equipment for driving the cylinder to rise and fall. When the cylinder is inserted into the valve seat driven by the lifting equipment, the cylinder prevents the closure of the magnetic valve cover. When the cylinder is out of contact with the magnetic valve cover driven by the lifting equipment, the magnetic valve cover is closed, and the worktable in the simulation device can rotate and turn over, so that the closing process of flap valve (valve seat and valve cover) in any direction of deep drilling coring under the action of magnetic force is simulated.

Simulation device for magnetic closing of flap valve

Disclosed is an isolated binding protein including a cardiac troponin I (cTnI) antigen binding domain, and preparation and a use and the like of the binding protein. The antigen binding domain includes at least one complementarity determining region selected from an amino acid sequence defined in this article, or has at least 80% sequence identity with the complementarity determining region of the amino acid sequence and has KD≤9.96×10mol/L affinity with cTnI. The binding protein may be used in the detection field of the cTnI protein.

Antibody against human cardiac troponin i and use thereof

The present disclosure relates to the field of medical diagnosis, and specifically, relates to a synthetic peptide for detecting HIV-1. The synthetic peptide is obtained by mutating the amino acid sequence set forth as SEQ ID NO: 1. The synthetic peptide can better detect anti-HIV-1 antibodies, and can better avoid potential 'false negative' and “false positive” results.

Synthetic peptide for detecting HIV-1

Disclosed is a continuous conduit apparatus based on guiding and injecting integrated mechanism, which comprises a straightening apparatus and a pair of sprocket and chain clamping assemblies. The pair of sprocket and chain clamping assemblies are configured to clamp the conduit and pull the conduit to go downwards a well or upwards a lifting direction. Between the pair of sprocket and chain clamping assemblies, a conduit guide channel applied for the conduit to passing through is formed. An inlet and an outlet of the conduit guide channel are not situated in a straight line, and the straightening apparatus are configured to straighten the conduit. Each of the two sprocket and chain clamping assemblies comprises a sprocket set, a chain, a plurality of clamping blocks mounted on the chain, and a pushing plate configured to press the clamping blocks.

Continuous conduit apparatus based on guiding and injecting integrated mechanism

Disclosed is a continuous conduit operation apparatus, which comprises a folding frame and a guiding and injecting integrated mechanism configured to pull the conduit to go downwards a well or upwards a lifting direction. The folding frame comprises a base, a mounting frame connected to the base in a movable connection, and a telescopic mechanism configured to rotate the mounting frame in a vertical plane around a position of the movable connection. One end of the telescopic mechanism is movably connected to the base, another end of the telescopic mechanism is movably connected to the mounting frame. The guiding and injecting integrated mechanism is arranged on the mounting frame. The present disclosure integrates the guiding function and the injection function to reduce the height of the apparatus and is suitable for operation environment with limited space and height.

Continuous conduit operation apparatus

A driving system for a core drilling rig has a driving motor. The driving motor has an outer rotor and an inner stator, and mutually-matched convex ribs are provided on the inner wall of the outer rotor and the outer wall of the inner stator. The outer rotor and the inner stator are in clearance fit. A clearance between the outer rotor and the inner stator is a driving liquid channel. The length of the outer rotor is less than that of the inner stator. The outer rotor is provided between the front and rear ends of the inner stator. The outer rotor is connected to an outer cylinder. The rear end of the inner stator is connected to a coupling.

Driving system for core drilling rig

A drilling fluid channel structure of a core drilling rig includes a fluid channel activation module, a pressure relief module, a flow diverging and blocking module, a driving fluid channel and a cooling fluid channel. The fluid channel activation module, the pressure relief module and the flow diverging and blocking module are connected sequentially from the rear to the front. The driving fluid channel and the cooling fluid channel are connected at the rear side thereof to the flow diverging and blocking module. The driving fluid channel includes a driving section located between a stator and a rotor of a driving motor. The driving fluid channel is provided with a driving fluid outlet at the front side of the driving section. The cooling fluid channel passes through a layer disposed between an integrity-preserving compartment and an outer barrel.

Drilling fluid channel structure of core drilling rig

A core sampling and preservation system comprises the following sequentially connected modules: a drive module (), a preservation module () and a core sampling module (). The core sampling module () comprises a core drilling tool and a core sample storage compartment. The preservation module () comprises a core sample preservation container. The drive module comprises a core drill having a liquid channel. The core sample preservation container comprises an inner core barrel (), an outer core barrel () and an energy storage device (). The outer core barrel () is sleeved onto the inner core barrel (). An upper end of the inner core barrel () is in communication with a liquid nitrogen storage tank (). The liquid nitrogen storage tank () is positioned inside the outer core barrel (). The energy storage device () is in communication with the outer core barrel (). The outer core barrel () is provided with a butterfly valve (). The system facilitates preserving a core at in-situ conditions, and has an increased drilling speed, thereby enhancing core sampling efficiency.

Core sampling and preservation system

Growing community of inventors

Shenzhen, China

Zhiqiang He