Cardax Pharmaceuticals, Inc.

Synchem, Inc.

Cardax Pharma, Inc.

Zhiqiang Fang

Peng Cho Tang

William Bert Geiss

Henry Lee Jackson

Samuel Fournier Lockwood

Geoff Nadolski

Richard Williams

David C Burdick

Yishu Du

Min Yang

Ze-Qi Xu

Qianli Wang

Augustine Rudolph Joseph

Henry L Jackson

William Geiss

David Burdick

The present invention relates to linker molecules that readily conjugate cellular recognition ligand at one end and drug payload at the other, and are useful in treating or preventing cancer, an autoimmune disease, an inflammatory condition, a central nervous system disorder or an infection. The linker inker molecules of the invention are represented by Formula I, II and III; Linker-Drug compounds represented by Formula IV, V and VI; and Ligand-Linker-Drug conjugates represented by Formula VII, VIII and IX: 

Thiol-ene click chemistry for drug conjugates

A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates

A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.

Methods for the synthesis of astaxanthin

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Hawthorn Woods, IL, United States of America

Zhiqiang Fang