Shanghai Kexin Biotech Co., Ltd.

Zhinan Shou

Yue Zhang

Hua Mao

Weina Situ

Jun Bao

Hongbin Sun

Jie Qian

Yongjun Han

Xiaofeng Zeng

The present application provides compositions and methods useful for detecting and monitoring autoimmune diseases in a human subject. The methods comprise providing a moesin fragment for binding to an anti-moesin autoantibody and contacting the moesin fragment with a sample obtained from the human subject. The moesin fragment comprises the entire N-terminal FERM domain of a human moesin protein. The human subject has or is suspected of having an autoimmune disease such as connective tissue disease, systemic sclerosis, Sjogren's syndrome, or systemic lupus erythematosus.

Moesin fragments and uses thereof

The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.

Moesin modulators and uses thereof

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Shanghai, China

Zhinan Shou