Oriental (luzhou) Agrochemicals Co., Ltd.

Zhejiang Dsm Zhongken Biotechnology Co. Ltd

Zhiming Zhang

Bangchi Chen

Junliang Wang

Qiuju Sheng

Rongming Wu

Jieping Shi

Xuegang Wang

Jialiang Wang

Huaiyuan Xu

Yubin Shen

Liqiang Yang

Xiaodong Du

Disclosed is a method of synthesizing 1,2,4-triazole-3-thione compounds and intermediates thereof. The method includes reacting a hydrazine with glyoxylic acid to form a hydrazono acetic acid intermediate followed by reacting the latter with thiocyanate to obtain the 1,2,4-triazole-3-thione compound. The raw materials involved in the present method are readily available, and the reaction is very specific in terms of regioselectivity, resulting in minimum by-product and high product yield. There are neither specific requirements for special equipment nor special operations such as high vacuum, high temperature, anhydrous and oxygen-free manipulations. The process is simple and generates minimum wastes, suitable for industrial production.

Method of synthesizing l,2,4-triazole-3-thione compounds and intermediates thereof

Disclosed are a method of synthesizing prothioconazole and optically active isomers thereof and intermediates. The method includes reacting hydrazine with glyoxylic acid to produce a hydrazono acetic acid as an intermediate, and then reacting the intermediate with thiocyanate to produce the target product prothioconazole. The present method is very specific in terms of regioselectivity, resulting in minimum byproducts and a high product yield. The present method does not require special equipment, nor anhydrous or oxygen-free manipulations. The process is simple and generates minimum wastes, suitable for industrial production.

Method of synthesizing prothioconazole and optically active isomers thereof and intermediates

Disclosed is a method for extracting high acyl gellan from the fermentation broth containing gellan gum with a low production cost and high quality of products, comprising the following steps: (1) Treatment of the fermentation broth with an enzyme; (2) flocculation of the treated fermentation broth with acid; (3) wash of the fiber-like material; and (4) drying and milling.

Method for post-extracting high-acyl gellan gum

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Zhejiang, China

Zhiming Zhang