Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Centaurus Biopharma Co., Ltd.

Lianyungang Runzhong Pharmaceutical Co., Ltd.

Zhilin Chen

Fei Liu

Hongjiang Xu

Xin Tian

Song Tang

Yi Xu

Shang Wang

Xiquan Zhang

Ping Dong

Yizhong Zhu

Hongmei Gu

Xinlu Li

Weiwei Feng

Zhongyuan Hu

Xifeng Lu

Jing Gao

Min Li

Xiandong Zhao

Peng Sun

Jianghui Jing

Haishan Zang

Lihui Dong

Shan Zhou

Laicun Li

Jie Zhou

Yuanyuan Sun

Lei Liu

Jinfeng Jiang

Yayu Zhang

Yan Peng

A solid pharmaceutical composition comprising a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine, a preparation method therefor, and an medical application thereof. The solid pharmaceutical composition has excellent stability and dissolution properties.

Solid pharmaceutical composition comprising TLR7 agonist

A solid pharmaceutical composition containing a 1,3,5-triazine derivative or a pharmaceutically acceptable salt thereof and a preparation method therefor. In particular, involved are a solid pharmaceutical composition containing 4-(tert-butoxyamino)-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazine-2-amine or a pharmaceutically acceptable salt thereof and a preparation method therefor. The solid pharmaceutical composition has a good stability, a fast dissolution rate and a high bioavailability, and is suitable for clinical production and use.

Solid pharmaceutical composition containing 1,3,5-triazine derivative or salt thereof

Disclosed are a crystal of a maleate of a compound of formula (I), a preparation method for the crystal, a crystallization composition of same, a pharmaceutical composition of same, and uses thereof in preventing and treating a tumor. 

Crystal of salt of quinazoline derivative

The present invention belongs to the field of drug crystals, relates to crystals of thiadiazole derivative DPP-IV inhibitors, and in particular relates to A and B type crystals of the compound as shown in formula 7. The crystals of the present invention have excellent stability. For example, under high temperature, high humidity or light test conditions, the material contents associated with the crystal of the compound of formula 7 do not change significantly. In addition, the crystal of the present invention also has a very good powder flowability and satisfies the requirements of drug preparation and production. 

Crystals of thiadiazole derivative DPP-IV inhibitors and uses thereof

The present application relates to maleates of a compound of Formula I, methods for preparing the same, pharmaceutical compositions thereof and uses thereof in the treatment of tumors, such as non-small cell lung cancer, breast cancer, and other malignant tumors. 

Salts of quinazoline derivative and method for preparing the same

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Lianyungang, China

Zhilin Chen