Hong Kong Baptist University

Changshu Hkbu Technology Company Limited

Zhijun Yang

Zhaoxiang Bian

Aiping Lu

Chengyuan Lin

Albert Sun Chi Chan

Huaixue Mu

Blenda Chi Kwan Wong

Xiaoyu Chen

Jinjin Wang

The present invention provides a slow and controlled released liposomal gel composition for subcutaneous administration comprises insulin or exenatide as active ingredient for reduction of blood sugar level and method of preparation thereof. Said controlled released composition has high bioavailability and is demonstrated to be able to sustain release therapeutically effective concentration of drug over a period of time and without rapid release of drug after initial administration. Method of preparing the controlled released composition of the present invention comprises the following steps: mixing insulin or exenatide, lipid and aqueous dispersion medium together; then mixing with poloxamer (e.g. F127 or P123) and/or gelatin and hyaluronic acid (HA) or the like gel solution so as to form a protective layer on surface of every lipid micro vesicles or nano-vesicles for use in intramuscular, abdominal and subcutaneous administration. A single administration of the present composition lasts 2 to 7 days to reduce side-effects, such as pain and irritation.

Slow and controlled released liposomal gel composition comprising hypoglycemic active ingredient and method of preparing thereof

The present invention relates to the bioactive components with the anti-proliferative property. In particular, the invention relates to one flavonol compound isolated from the root ofLinn. Thwait or chemically synthesized and its specific anticancer/antitumor activity. This invention has a specific application in treating human esophageal cancer.

Anti-esophageal cancer compound and method of use thereof

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Hong Kong, China

Zhijun Yang